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Macroscale connectome topographical structure reveals the biomechanisms of brain dysfunction in Alzheimer's disease.
Sci Adv
October 2024
School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China.
Article Synopsis
- The study examines how brain networks change with aging and neurodegenerative diseases, using MRI data from over 7,300 participants to identify unique patterns related to conditions like Alzheimer's disease (AD).
- Gene analysis revealed that normal aging involves significant transport of inorganic ions, while different neurodegenerative diseases share a focus on chemical synaptic transmission.
- Findings highlight that each disorder presents specific neurophysiological issues, helping to clarify the biological mechanisms behind AD compared to normal aging and other disorders.
Abnormal Structural-Functional Coupling and MRI Alterations of Brain Network Topology in Progressive Supranuclear Palsy.
J Magn Reson Imaging
September 2024
Department of Radiology, Qilu Hospital of Shandong University, Qilu Medical Imaging Institute of Shandong University, Jinan, China.
Background: Progressive supranuclear palsy (PSP) can cause structural and functional brain reconstruction. There is a lack of knowledge about the consistency between structural-functional (S-F) connection networks in PSP, despite growing evidence of anomalies in various single brain network parameters.
Purpose: To study the changes in the structural and functional networks of PSP, network's topological properties including degree, and the consistency of S-F coupling.
Resonant inductive coupling network for human-sized magnetic particle imaging.
Rev Sci Instrum
April 2024
Fraunhofer Research Institution for Individualized and Cell-based Medical Engineering, IMTE, 23562 Lübeck, Germany.
In magnetic particle imaging, a field-free region is maneuvered throughout the field of view using a time-varying magnetic field known as the drive-field. Human-sized systems operate the drive-field in the kHz range and generate it by utilizing strong currents that can rise to the kA range within a coil called the drive field generator. Matching and tuning between a power amplifier, a band-pass filter, and the drive-field generator is required.
View Article and Find Full Text PDFImproving Magnetic STEM-Differential Phase Contrast Imaging using Precession.
Microsc Microanal
April 2023
Department of Physics, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway.
Differential phase contrast in scanning transmission electron microscopy (STEM-DPC) is a technique used to image electromagnetic fields in materials. STEM-DPC is based on tracking the minute changes in the position of the bright-field disk, so any effects which cause inhomogeneities in the intensity or geometry of the disk can lead to the contrast from the electromagnetic fields to be obscured. Structural changes, like grain boundaries, thickness variations, or local crystallographic orientation, are a major cause of these inhomogeneities.
View Article and Find Full Text PDFQuantitative electric field mapping between electrically biased needles by scanning transmission electron microscopy and electron holography.
Ultramicroscopy
November 2023
Department of Chemistry and Centre for NanoScience, Ludwig-Maximilians-Universität München, Butenandtstrasse 11, 81377 Munich, Germany; Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C), Forschungszentrum Jülich, 52425 Jülich, Germany. Electronic address:
Stray electric fields in free space generated by two biased gold needles have been quantified in comprehensive finite-element (FE) simulations, accompanied by first moment (FM) scanning TEM (STEM) and electron holography (EH) experiments. The projected electrostatic potential and electric field have been derived numerically under geometrical variations of the needle setup. In contrast to the FE simulation, application of an analytical model based on line charges yields a qualitative understanding.
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