Addition of in situ generated di- or trisubstituted alkenylalanes to N-acyliminium ions provides rapid access to functionalized isoindolinones. Subsequent ring closing metathesis leads to tricyclic products. These transformations proceed under mild conditions and allow for the convergent synthesis of biologically significant scaffolds from readily available starting materials.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726970PMC
http://dx.doi.org/10.1016/j.jorganchem.2007.05.035DOI Listing

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