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| http://dx.doi.org/10.1113/jphysiol.2009.177816 | DOI Listing |
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Glutamate Signaling and Neuroligin/Neurexin Adhesion Play Opposing Roles That Are Mediated by Major Histocompatibility Complex I Molecules in Cortical Synapse Formation.
J Neurosci
December 2024
Center for Neuroscience, University of California, Davis, Davis, California 95618
Article Synopsis
- Neurons release neurotransmitters like glutamate before establishing connections, but the specific impact of this release on synapse formation is not well understood.
- Research indicates that synapses in the cortex don’t necessarily need this neurotransmitter release for formation, yet glutamate influences receptor movement and stimulates spine development in neurons.
- The study reveals that glutamate can decrease synapse density in young cortical neurons in a calcium-dependent manner, but this effect is mitigated by the adhesion molecules NL1 and neurexin 1, highlighting the complex interplay between glutamate, neurotransmitter release, and synaptic stability.
Intersectin-1 enhances calcium-dependent replenishment of the readily releasable pool of synaptic vesicles during development.
J Physiol
October 2024
Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada.
Article Synopsis
- Intersectin-1 (Itsn1) is a protein that helps with sending and receiving signals in the brain, especially in a part called the calyx of Held synapse.
- Researchers looked at mice with and without Itsn1 to see how it affected their hearing and signal transmission as they grew up.
- They found Itsn1 is really important for helping the synapse work well, especially in mature mice, as it helps replenish the resources needed for sending signals quickly after they’ve been used.
Jasmonic acid mediates Ca dependent signal transduction and plant immunity.
Plant Sci
November 2024
National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, College of Life and Environmental Science, Wenzhou University, Zhong-Xin Street, Wenzhou 325035, China; Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Zhong-Xin Street, Wenzhou 325035, China. Electronic address:
Pathogen attacks can cause significant damage to plants, posing a threaten to global food production. Plants have developed exquisite methods to rapidly store a key defensive hormone jasmonate (JA), which stimulates their entire evolutionary adaptive response to pathogen attack. However, understanding how plants initiate JA biosynthesis in response to pathogen attacks has remained elusive.
View Article and Find Full Text PDFCRISPR-Cas9-mediated construction of a cotton CDPK mutant library for identification of insect-resistance genes.
Plant Commun
November 2024
Hubei Hongshan Laboratory, National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
Calcium-dependent protein kinases (CDPKs) act as key signal transduction enzymes in plants, especially in response to diverse stresses, including herbivory. In this study, a comprehensive analysis of the CDPK gene family in upland cotton revealed that GhCPKs are widely expressed in multiple cotton tissues and respond positively to various biotic and abiotic stresses. We developed a strategy for screening insect-resistance genes from a CRISPR-Cas9 mutant library of GhCPKs.
View Article and Find Full Text PDFStable and reusable calcium-responsive biopolymer for affinity precipitation of therapeutic antibodies.
Protein Sci
August 2024
Center for Convergence Bioceramic Materials, Korea Institute of Ceramic Engineering and Technology, Cheongjusi, Chungcheongbuk-do, South Korea.
Affinity precipitation is an attractive method for protein purification due to its many advantages, including the rapid capture of target proteins, simple processing, high specificity, and ease of scale-up. We previously reported a robust antibody purification method using Ca-dependent precipitation of ZZ-hCSQ2, a fusion protein of human calsequestrin 2, and the antibody-binding protein ZZ. However, the stability of this fusion protein was not sufficiently high for industrial use because the antibody recovery yield decreased to 60% after being reused 10 times.
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