It is widely recognized that groundwater flow and solute transport in natural media are largely controlled by heterogeneities. In the last three decades, many studies have examined the effects of heterogeneous hydraulic conductivity fields on flow and transport processes, but there has been much less attention to the influence of heterogeneous porosity fields. In this study, we use porosity and particle size measurements from boreholes at the Boise Hydrogeophysical Research Site (BHRS) to evaluate the importance of characterizing the spatial structure of porosity and grain size data for solute transport modeling. Then we develop synthetic hydraulic conductivity fields based on relatively simple measurements of porosity from borehole logs and grain size distributions from core samples to examine and compare the characteristics of tracer transport through these fields with and without inclusion of porosity heterogeneity. In particular, we develop horizontal 2D realizations based on data from one of the less heterogeneous units at the BHRS to examine effects where spatial variations in hydraulic parameters are not large. The results indicate that the distributions of porosity and the derived hydraulic conductivity in the study unit resemble fractal normal and lognormal fields respectively. We numerically simulate solute transport in stochastic fields and find that spatial variations in porosity have significant effects on the spread of an injected tracer plume including a significant delay in simulated tracer concentration histories.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jconhyd.2009.06.001 | DOI Listing |
Introduction: In USA, six million individuals with Sub-Saharan ancestry carry two high-risk variants, which increase the risk for kidney diseases. Whether APOL1 high-risk variants are independent risk factors for cardiovascular diseases is unclear and requires further investigation.
Methods: We characterized a mouse model to investigate the role of APOL1 in dyslipidemia and cardiovascular diseases.
Atheroscler Plus
March 2025
Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Background And Aims: Familial hypercholesterolemia (FH) and other disorders with similar features are common genetic disorders that remain underdiagnosed and undertreated, due in part to the cost of screening. The aim of this study was to design and implement a whole gene targeted NGS panel for the molecular diagnosis of FH and statin intolerance with an emphasis on high quality variant calling, including copy number analysis.
Methods: A whole gene panel for hybridisation-based short read NGS was designed for the dominant FH-genes low density lipoprotein receptor (), apolipoprotein B (APOB), proproteinconvertas subtilisin/kexin type 9 (PCSK9), apolipoprotein E (APOE) and the recessive FH-genes low density lipoprotein receptor adaptor protein 1 (), ATP binding cassette subfamily member 5/8 (ABCG5/8) and lipase A, lysosomal acid type (), as well as solute carrier organic anion transporter family member 1B1 (), not an FH gene but linked to statin intolerance.
Urban Inform
January 2025
IVL Swedish Environmental Research Institute LTD., PO Box 530 21, SE-400 14 Gothenburg, Sweden.
In response to the demand for advanced tools in environmental monitoring and policy formulation, this work leverages modern software and big data technologies to enhance novel road transport emissions research. This is achieved by making data and analysis tools more widely available and customisable so users can tailor outputs to their requirements. Through the novel combination of vehicle emissions remote sensing and cloud computing methodologies, these developments aim to reduce the barriers to understanding real-driving emissions (RDE) across urban environments.
View Article and Find Full Text PDFACS Mater Au
January 2025
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. China.
The integration of fluorinated benzothiadiazole (FBT) into donor-acceptor (D-A) copolymers represents a major advancement in the field of organic solar cells (OSCs). The fluorination process effectively fine-tunes the energy levels, reduces the highest occupied molecular orbital levels, and enhances the open-circuit voltages of the polymers. Furthermore, fluorination improves molecular packing and crystallinity, which significantly boosts the charge transport and overall device performance.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Industrial Engineering, Università degli Studi di Firenze, Via di Santa Marta, 3, 50139, Firenze, Italy.
The rise of Personal Light Electric Vehicles (PLEVs), including electric bicycles and electric kick scooters, represents a relevant trend in current urban mobility. PLEVs offer economic, social, and environmental advantages, making them increasingly attractive for short-distance travel. Despite their benefits, concerns about the safety of PLEVs, particularly related to road accidents, have arisen due to their growing presence in urban areas.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!