Background: The influence of male or female sex on newborn outcomes has been recognized for >30 years. Several studies have observed higher mortality and morbidity in males than in females. It is not clear how this sex difference is sustained in postnatal complications such as intraventricular hemorrhage (IVH), especially in very low birth weight (VLBW) newborns.
Objective: This study examined possible sex-related differences in IVH rates among VLBW neonates.
Methods: In a retrospective observational study conducted in Hospital Privado, Córdoba, Argentina, data from 332 consecutive VLBW newborns in a 12-year period were reviewed. Maternal factors, labor and delivery characteristics, and neonatal parameters, including the results of cranial ultrasound examination to detect IVH, were compared for males and females. Bivariate and multivariate logistic regression analyses were performed.
Results: A total of 322 VLBW newborns were included, 168 males and 154 females. Compared with female neonates, male neonates had a higher risk of overall IVH (26.8% vs 9.7%; odds ratio [OR] = 3.4 [95% CI, 1.8-6.4]; P < 0.001) and for grades III or IV on the Papile scale (16.1% vs 1.9%; OR = 9.6 [95% CI, 2.9-32.5]; P < 0.001). In the multivariate logistic regression model, male sex sustained the association with a greater risk of IVH (OR = 6.8 [95% CI, 3.8-12.0]).
Conclusions: IVH was significantly associated with male sex in these VLBW newborns. Because other factors affect these differences, further research is required.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.genm.2009.06.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transition to competent oral feeding in preterm infants: Analyzing timing and determinants.
An Pediatr (Engl Ed)
January 2025
Departamento de Enfermería, Unidad de Neonatología, Hospital Universitario de Burgos, Burgos, Spain.
Introduction: The achievement of oral feeding competence (OFC) is a challenge in preterm infants and can be affected by several factors.
Objective: The aim of our study was to determine the time elapsed to development of OFC in very low birth weight (VLBW, weight <1500g) preterm infants and to identify factors associated with greater difficulty in achieving this skill.
Population And Methods: Observational, longitudinal and prospective study in VLBW infants over a period of 7 years (2016-2022).
Device-measured physical activity in adults born preterm with very low birth weight and mediation by motor abilities.
PLoS One
January 2025
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Physical activity (PA) is beneficial for several health outcomes. Adults born with very low birth weight (VLBW<1500g) undertake less PA than those born at term, have poorer motor abilities and may serve as a model on early life origins of PA. We therefore examined whether motor abilities mediate the association between being born with VLBW and device-measured PA.
View Article and Find Full Text PDFUnlabelled: Hemodynamically significant patent ductus arteriosus (hs-PDA) in very low birth weight (VLBW) infants continues to be an issue of research regarding the timing of treatment and which would be the most appropriate drug.
Objective: To assess the outcome of prolonged treatment with paracetamol in the closure of hemodynamically significant patent ductus arteriosus in preterm newborns.
Patients And Method: Retrospective study in VLBW infants with echocardiographic and clinical diagnosis of hs-PDA who received treatment with intravenous paracetamol at 15 mg/kg every 6 hours for 6 days.
Untargeted metabolomics analysis of glycerophospholipid metabolism in very low birth weight infants administered multiple oil lipid emulsions.
BMC Pediatr
December 2024
Department of Intensive Care Unit, Hangzhou Women's Hospital, Hangzhou, 310016, Zhejiang, China.
Background: To compare the impact of two different lipid emulsions, specifically a soybean oil-based emulsion and a multiple oil emulsion (soybean oil, medium-chain triglycerides, olive oil, and fish oil, SMOF), on serum metabolites of very low birth weight (VLBW) infants using untargeted metabolomics analysis.
Methods: A comparative study was conducted on 25 VLBW infants hospitalized in neonatal intensive care units (NICU) of Hangzhou Women's Hospital in 2023. The infants were divided into the SMOF group (13 cases) and the soybean oil group (12 cases) based on the type of lipid emulsion used during parenteral nutrition.
Objective: In preterm and very low birth weight (VLBW) infants, attention-related problems have been found to be more pronounced and emerge later as academic difficulties that may persist into school age. In response, based on three attention networks: alerting, orienting, and executive attention, we examined the development of attention functions at 42 months (not corrected for prematurity) as a follow-up study of VLBW ( = 23) and normal birth weight (NBW: = 48) infants.
Method: The alerting and orienting attention networks were examined through an overlap task with or without warning signal.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!