Herpes simplex encephalitis during treatment with tumor necrosis factor-alpha inhibitors.

Russell D Bradford April C Pettit Patty W Wright Mark J Mulligan Larry W Moreland David A McLain John W Gnann Karen C Bloch

Clin Infect Dis

Division of Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Published: September 2009

We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-alpha) inhibitors for rheumatologic disorders. Although TNF-alpha inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF-alpha drugs and herpes simplex virus encephalitis has not been previously described.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315107	PMC
http://dx.doi.org/10.1086/605498	DOI Listing

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