Introduction: Skin cancer (basal cell carcinoma, squamous cell carcinoma) and melanoma are the most frequent malignancy appearing in a human begin. The treatment of choice is surgical excision of tumor with margins of healthy tissue. An extent of resection determines the method of reconstruction.
Material: The authors present reconstructive methods of nasal skin cancer defects performed in 61 patients treated in the Department of Otolaryngology of Medical University of Warsaw between 1998 and 2007. Basal cell carcinoma, squamous cell carcinoma and melanoma were diagnosed in 49, 10 and 2 patients respectively. Depending on the extend of tumor resection different reconstructive techniques were performed.
Results: In 9 patient tumor recurrence was detected during 1-2 years of follow-up. Among them, in 7 patients another reconstruction procedure was required, and 1 patient underwent several surgical procedures due to subsequent recurrences.
Conclusions: Surgical wounds after resection of skin cancer of the nose can be closed primarily or by means of variety of reconstructive techniques that in some cases may be combined depending on the extent of a defect.
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http://dx.doi.org/10.1016/S0030-6657(09)70091-5 | DOI Listing |
Mol Oncol
January 2025
Urologic Oncology Research Group, Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, Canada.
Patient stratification remains a challenge for optimal treatment of prostate cancer (PCa). This clinical heterogeneity implies intra-tumoural heterogeneity, with different prostate epithelial cell subtypes not all targeted by current treatments. We reported that such cell subtypes are traceable in liquid biopsies through representative transcripts.
View Article and Find Full Text PDFHead Neck
January 2025
Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Objectives: We aimed to compare the outcomes of patients with T1-T2N0M0 glottic squamous cell carcinoma who underwent either partial laryngectomy (PL) or radiotherapy (RT).
Methods: A retrospective analysis of 562 patients treated with RT (n = 151) or PL (n = 411) was conducted. The Kaplan-Meier method was used to estimate outcomes.
Cureus
December 2024
Department of Urology, Ehime University Graduate School of Medicine, Toon, JPN.
Background The accurate diagnosis of intraductal carcinoma of the prostate (IDC-P) is occasionally challenging due to the similarity in pathological morphology between IDC-P and high-grade prostatic intraepithelial neoplasia (HGPIN). In this report, we reviewed the pathology of cases previously diagnosed as HGPIN to search for IDC-P cases effectively. In addition, we examined whether those cases had genetic abnormalities.
View Article and Find Full Text PDFCureus
December 2024
Department of Pathology, Government Medical College Satna, Satna, IND.
Background Oral squamous cell carcinoma is a common problem among tobacco chewers and related products in developing countries like India. Histopathological examination evaluates and confirms the diagnosis of oral SCC. Clinical examination and molecular profiling by histopathological examination (HPE) are important prognostic tools used in clinical practice.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Purpose: The present work focused on assessing whether hepatic arterial infusion chemotherapy (HAIC) combined with lenvatinib and tislelizumab was safe and effective on advanced hepatocellular carcinoma (HCC) showing high tumor burden.
Methods: In the present multicenter retrospective study, treatment-naive advanced HCC patients (BCLC stage C) showing high tumor burden (maximum diameter of intrahepatic lesion beyond 7 cm) treated with lenvatinib and tislelizumab with or without HAIC were reviewed for eligibility from June 2020 to June 2023. Baseline differences between groups were mitigated by propensity score matching (PSM).
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