Microchemical systems for continuous-flow synthesis.

Lab Chip

MIT, 77 Massachusetts Avenue, Cambridge, MA, USA.

Published: September 2009

AI Article Synopsis

  • Microchemical systems have advanced considerably in the past ten years, facilitating the discovery and development of new synthetic methods while enhancing our understanding of chemical processes and kinetics.
  • This review highlights trends and important aspects of continuous-flow microchemical synthesis, discussing various operations and summarizing key literature in the field.
  • The article also outlines current challenges in microfabrication, micromixing, and multi-step synthesis, while providing insights into future directions and potential improvements related to microchemical systems.

Article Abstract

Microchemical systems have evolved rapidly over the last decade with extensive chemistry applications. Such systems enable discovery and development of synthetic routes while simultaneously providing increased understanding of underlying pathways and kinetics. We review basic trends and aspects of microsystems as they relate to continuous-flow microchemical synthesis. Key literature reviews are summarized and principles governing different microchemical operations discussed. Current trends and limitations of microfabrication, micromixing, chemical synthesis in microreactors, continuous-flow separations, multi-step synthesis, and integration of analytics are delineated. We conclude by summarizing the major challenges and outlook related to these topics.

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Source
http://dx.doi.org/10.1039/b906343aDOI Listing

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