AI Article Synopsis
- Periodontal diseases are infections caused by bacteria that trigger an inflammatory response in the body to the plaque and its by-products.
- Many bacteria in these infections have factors that can destroy tissue, either directly or indirectly through inflammation.
- The overview will focus on the body’s immune responses to this bacterial attack in periodontitis, including the role of specific receptors and immune components like CD14, the complement system, and various immune cells.
Article Abstract
Periodontal diseases are complex bacteria-induced infections characterised by an inflammatory host response to plaque microbiota and their by-products. Most of these microorganisms have virulence factors capable of causing massive tissue destruction both directly, through tissue invasion and the production of harmful substances, or indirectly, by activation of host defense mechanisms, creating an inflammatory infiltrate of potent catabolic activity that can interfere with normal host defense mechanisms. In response to the aggression, host defense mechanisms activate innate and adaptive immune responses. Our aim is to offer a general overview of the main mechanisms involved in the host response to bacterial aggression in periodontitis, such as lipopolysaccharide receptor CD14, complement system, polymorphonuclear neutrophils, antibodies and immunoglobulins.
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| http://dx.doi.org/10.4317/medoral.14.e680 | DOI Listing |
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