HAHA--nothing to laugh about. Measuring the immunogenicity (human anti-human antibody response) induced by humanized monoclonal antibodies applying ELISA and SPR technology.

J Pharm Biomed Anal

Vela pharmazeutische Entwicklung und Laboranalytik GmbH, Brunner Strasse 69, Vienna, Austria.

Published: January 2010

Immunogenicity induced by passively applied proteins is a serious issue because it is directly related to the patient's safety. The out-come of an immune reaction to a therapeutic protein can range from transient appearance of antibodies without any clinical significance to severe life threatening conditions. Within this article, enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance (SPR) methodology to measure immunogenicity are compared and the pros and cons are discussed.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2009.07.013DOI Listing

Publication Analysis

Top Keywords

haha--nothing laugh
4
laugh measuring
4
measuring immunogenicity
4
immunogenicity human
4
human anti-human
4
anti-human antibody
4
antibody response
4
response induced
4
induced humanized
4
humanized monoclonal
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!