AI Article Synopsis
- Oxidative stress contributes to aging and noise-induced damage in the cochlea, prompting a study on enzyme activity related to hydrogen peroxide removal in different aged rats.
- Significant increases in glutathione peroxidase (Gpx) activity were observed in vascular tissues, indicating an age-related response, while catalase activity showed elevation mainly in vestibular tissue.
- The results imply that higher Gpx activity in cochlear vascular tissues may compensate for lowered glutathione levels and a deteriorating redox state as the rats age.
Article Abstract
Oxidative stress is a pervasive factor in aging and has been implicated in noise-induced cochlear pathology. In this study, we measured the activities of two enzymes that catalyze the removal of hydrogen peroxide (H(2)O(2)), catalase and glutathione peroxidase (Gpx), in 3- and 24-month-old Fisher-344 rats, and reduced and oxidized glutathione in 3-, 12-, and 24-month-old rats. There was an increase in Gpx activity in vascular tissue (spiral ligament and stria vascularis), but no change in modiolar, sensory or vestibular tissue of the cochlea. The elevation in vascular tissue was age-related. We observed a significant elevation of catalase activity in vestibular tissue, a tendency for age-related elevation in the modiolus, but no change in vascular or sensory cochlear tissue. These findings suggest that increased Gpx activity in vascular cochlear tissue may be an age-related compensation for a decrease in glutathione and a decline in the redox state measured by the ratio of reduced to oxidized glutathione.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760401 | PMC |
| http://dx.doi.org/10.1016/j.neulet.2009.08.015 | DOI Listing |
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