This article provides an overview of meningitis and meningococcal septicaemia, which can have devastating effects. Nurses working in acute and primary care need to be able to recognise the causes and symptoms of these conditions, and have up-to-date knowledge of treatment, prevention and potential after-effects.
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Empowering African Expertise: Enhancing Safety Data Integration and Signal Detection for COVID-19 Vaccines Through the African Union Smart Safety Surveillance Joint Signal Management Group.
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January 2025
Department of Public Health Pharmacy and Management, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Introduction: The COVID-19 pandemic accelerated new vaccine development. Limited safety data necessitated robust global safety surveillance to accurately identify and promptly communicate potential safety issues. The African Union Smart Safety Surveillance (AU-3S) program established the Joint Signal Management (JSM) group to support identification of potential vaccine safety concerns in five pilot countries (Ethiopia, Ghana, Kenya, Nigeria, South Africa), accounting for approximately 35% of the African population.
View Article and Find Full Text PDFNavigating translational research in nanomedicine: A strategic guide to formulation and manufacturing.
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January 2025
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region; Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, Hong Kong Special Administrative Region. Electronic address:
Over the past two decades, extensive research has focused on both the fundamental and applied aspects of nanomedicine, driven by the compelling advantages that nanoparticles offer over their bulk counterparts. Despite this intensive research effort, fewer than 100 nanomedicines have been approved by the U.S.
View Article and Find Full Text PDFGroup B streptococcal infections in pregnancy and early life.
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Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, USA.
SUMMARYBacterial infections with Group B (GBS) are an important cause of adverse outcomes in pregnant individuals, neonates, and infants. GBS is a common commensal in the genitourinary and gastrointestinal tracts and can be detected in the vagina of approximately 20% of women globally. GBS can infect the fetus either during pregnancy or vaginal delivery resulting in preterm birth, stillbirth, or early-onset neonatal disease (EOD) in the first week of life.
View Article and Find Full Text PDFNeuroimaging Spectrum of Erdheim-Chester Disease: An Image-based Review.
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From the (1) Department of Radiology, Tata Memorial Hospital, Parel, Mumbai 400012 (P.R.), (2) Department of Radiology, Mayo Clinic, Rochester, MN (H.J.S, J.C.B, S.A.M, P.J.F, C.M.C, G.B.), and (3) Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 55902 (N.S., A.A), and The authors have no relevant disclosures of interest.
Erdheim-Chester Disease (ECD) is a rare, multisystem histiocytic disorder characterized by its variable clinical presentations. Central Nervous System (CNS) involvement is observed in approximately half of ECD patients (up to 76% in some series), and often carries a poorer prognosis. While CNS involvement may remain asymptomatic, others may experience a range of neurological symptoms, including cognitive decline, neuropsychiatric disturbances, motor deficits, cranial or peripheral neuropathies, and endocrine abnormalities.
View Article and Find Full Text PDF[Diagnosis of neuroinfections in children].
Zh Nevrol Psikhiatr Im S S Korsakova
November 2024
Children's Research and Clinical Center for Infectious Disease, St. Petersburg, Russia.
Presents an overview of domestic and foreign sources on the diagnosis of neuroinfections in children of different etiologies based on epidemiological, physical, cerebrospinal fluid, etiological, radiation and other methods. Their combination makes it possible to establish the syndrome of neuroinfection (meningitis, encephalitis, myelitis, polyradioloneuritis, etc.), the severity, the presence of complications, the nature of the course, etiology.
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