Hypothesis: Helicobacter pylori, urease, mucus, and gastric ulcer.

Lancet

Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Published: January 1990

Ammonia, released in the gastric mucosa by the action of Helicobacter pylori urease on transuded plasma urea, curtails the biosynthesis of mucus and/or causes the mucus to be disassembled at the mucosal surface. These changes facilitate colonisation by H pylori and may promote gastric ulcer formation.

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Source
http://dx.doi.org/10.1016/0140-6736(90)90279-eDOI Listing

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