Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Role of Anti-Inflammatory Diet and Fecal Microbiota Transplant in Psoriatic Arthritis.
Clin Ther
July 2024
Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Science, School of Biological Sciences, Faculty of Biological Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Article Synopsis
- Psoriatic arthritis (PsA) is a serious inflammatory condition with no known cure, though various treatments, including biologics, exist to manage symptoms and disease progression.
- Recent studies suggest that dietary changes, particularly anti-inflammatory diets and fecal microbiota transplants (FMT), may offer new strategies for treating PsA.
- Evidence supports the effectiveness of hypocaloric and Mediterranean diets in reducing inflammation and improving health for overweight PsA patients, but more research is needed on the impact of FMT and other dietary supplements.
Gut microbiome and metabolome to discover pathogenic bacteria and probiotics in ankylosing spondylitis.
Front Immunol
May 2024
Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Objective: Previous research has partially revealed distinct gut microbiota in ankylosing spondylitis (AS). In this study, we performed non-targeted fecal metabolomics in AS in order to discover the microbiome-metabolome interface in AS. Based on prospective cohort studies, we further explored the impact of the tumor necrosis factor inhibitor (TNFi) on the gut microbiota and metabolites in AS.
View Article and Find Full Text PDFTransforming Psoriasis Care: Probiotics and Prebiotics as Novel Therapeutic Approaches.
Int J Mol Sci
July 2023
Department of Internal Medicine, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Phamacy, 400423 Cluj-Napoca, Romania.
Psoriasis is a chronic inflammatory skin disease with autoimmune pathological characteristics. Recent research has found a link between psoriasis, inflammation, and gut microbiota dysbiosis, and that probiotics and prebiotics provide benefits to patients. This 12-week open-label, single-center clinical trial evaluated the efficacy of probiotics ( (HU36), (HU58), (SC208), (SL307), and (SC109)) and precision prebiotics (fructooligosaccharides, xylooligosaccharides, and galactooligosaccharides) in patients with psoriasis receiving topical therapy, with an emphasis on potential metabolic, immunological, and gut microbiota changes.
View Article and Find Full Text PDFImpact of Gut Bacterial Metabolites on Psoriasis and Psoriatic Arthritis: Current Status and Future Perspectives.
J Invest Dermatol
September 2023
Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:
There is growing evidence that supports a role of gut dysbiosis in the pathogenesis of psoriasis (Pso). Thus, probiotic supplementation and fecal microbiota transplantation may serve as promising preventive and therapeutic strategies for patients with Pso. One of the basic mechanisms through which the gut microbiota interacts with the host is through bacteria-derived metabolites, usually intermediate or end products produced by microbial metabolism.
View Article and Find Full Text PDFEffects of synbiotic supplementation on regulatory T cells' response in patients with axial spondyloarthritis: a randomized double-masked placebo-controlled trial.
Food Funct
December 2022
Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
This study was conducted on samples from patients enrolled in a randomized double-masked placebo-controlled trial on the effect of synbiotic supplementation on the IL-17/IL-23 pathway and disease activity in patients with axial spondyloarthritis (axSpA) to investigate the effects of synbiotic supplementation on regulatory T (Treg) cells' response in these patients. Forty-eight axSpA patients were randomized to take one synbiotic capsule or placebo daily for 12 weeks. Treg cell proportion, gene expression of forkhead box protein P3 (Foxp3), microRNA (miRNA)-25, miRNA-106b, miRNA-146a, interleukin (IL)-10, and transforming growth factor (TGF)-β as well as serum IL-10 and TGF-β levels were assessed before and after the trial.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!