Aim: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer.
Methods: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.
Results: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer.
Conclusion: Our study does not support PTEN as a colon cancer susceptibility gene.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726455 | PMC |
| http://dx.doi.org/10.3748/wjg.15.3771 | DOI Listing |
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