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Atypical Anti-glomerular Basement Membrane Disease in a 16-Year-Old Male Child: A Case Report.
Cureus
February 2025
Pediatrics, Valley Children's Healthcare, Madera, USA.
Anti-glomerular basement membrane (anti-GBM) disease is an extremely rare small vessel vasculitis, which typically presents as rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Atypical anti-GBM disease varies in its clinical and laboratory presentation with insidious onset of symptoms. We present the case of a 16-year-old male child who presented with a two-week history of fever, weight loss, cough, hemoptysis, shortness of breath, and a five-year history of intermittent emesis.
View Article and Find Full Text PDFEarly Initiation of Hydroxychloroquine in Cutaneous Lupus Erythematosus to Prevent Progression to Systemic Lupus Erythematosus: A Long-term Follow-up Study.
J Am Acad Dermatol
February 2025
Department of Rheumatology, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel; Division of Rheumatology, Sheba medical center, Ramat-Gan, Israel.
Background: The progression from cutaneous lupus erythematosus (CLE) to systemic lupus erythematosus (SLE) remains a significant clinical challenge, with identified risk factors but no established preventative strategies.
Objectives: To evaluate whether early hydroxychloroquine (HCQ) initiation reduces the risk of CLE progressing to SLE.
Methods: A longitudinal study of 286 consecutive patients with isolated CLE (full study cohort), treated with HCQ (n = 186) or topical corticosteroids/calcineurin inhibitors (TCS/CNI; n =100).
A cross-sectional study on white matter hyperitensity in patients at the initial diagnosis of neuropsychiatric SLE: Correlation with Clinical and Laboratory Findings.
Clin Rheumatol
February 2025
Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Peking University People's Hospital, Department of Rheumatology and Immunology, No. 11, Xizhimen South Street, Xicheng District, Beijing, China.
Objectives: This study aimed to investigate the differences between neuropsychiatric systemic lupus erythematosus (NPSLE) patients with and without white matter hyperintensity (WMH) on magnetic resonance imaging (MRI) and to identify factors independently associated with the development of WMH in NPSLE.
Method: A comparative analysis was conducted on 84 NPSLE patients hospitalized at Peking University People's Hospital from 2015 to 2022 at the initial diagnosis of NPSLE. Patients were categorized based on the presence of WMH on brain MRI scans.
infection induces autoimmune hepatitis in mice.
J Transl Autoimmun
June 2025
College of Veterinary Medicine, Institute of Comparative Medicine, Yangzhou University, Yangzhou, China.
Background: Autoimmune hepatitis (AIH) is a chronic progressive liver disease caused by the immune system mistakenly attacking its own hepatocytes. The role of the gut microbiome in the pathogenesis and progression of AIH is of considerable significance. However, the dearth of suitable animal models has significantly constrained advancements in the pathogenesis and the development of therapeutic strategies for AIH.
View Article and Find Full Text PDFA rare case of unexplained recurrent intracerebral haemorrhage.
J Surg Case Rep
February 2025
Department of Orthopedics Center, Caoxian People's Hospital, Heze, China.
Recurrent intracerebral haemorrhage (ICH) presents a complex clinical challenge that eludes traditional diagnostic and treatment approaches. We report a rare and unexplained case of a middle-aged patient with recurrent ICH, for which extensive multidisciplinary investigations have yet to provide a definitive diagnosis or an effective long-term treatment strategy. Intraoperative pathology, genetic testing, cerebral angiography, inflammatory markers (erythrocyte sedimentation rate, C-reactive protein), specific antibodies (ANCA, anti-nuclear antibodies), and immunoglobulin levels showed no specific positive findings.
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