First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Published: October 2009
AI Article Synopsis
Article Abstract
Objectives: To evaluate the response of patients with SS to mizoribine therapy in relation to histological features of minor salivary glands.
Methods: Forty patients definitely diagnosed as having SS were treated with mizoribine (150 mg/day). Thirty-four untreated patients matched for age, baseline salivary secretion, etc., served as controls. Salivary secretion volume (measured by the Saxon test) and serum IgG level were measured before and after 24 weeks of treatment. Each histological finding (lymphocytic infiltration, acinar atrophy and intralobular fibrosis) was graded at baseline and the therapeutic responses were compared with the grade at 24 weeks in both the groups.
Results: There was a significant increase of the salivary secretion volume after treatment with mizoribine as compared with the untreated control group. The effect of mizoribine on salivary secretion was more marked in patients having moderate lymphocytic infiltration and moderate or less severe acinar atrophy and intralobular fibrosis at baseline.
Conclusions: Mizoribine was clinically effective in patients with SS whose minor salivary glands had moderate cell infiltration and were free of intralobular fibrosis. The drug was less effective in patients who presented intralobular fibrosis. Histological evaluation of the minor salivary glands may serve to predict the response of SS patients to mizoribine therapy.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment and memory deficit. Even with extensive research and studies, presently, there is no effective treatment for the management of AD. Besides, most of drugs used in the treatment of AD did not avert the AD neuropathology, and the disease still in a progressive status.
Background: Xerostomia is a common and difficult symptom experienced by patients with cancer. Pilocarpine is a cholinergic agent that stimulates salivation.
Aim: To assess the feasibility of conducting a N-of-1 trial to determine the efficacy of pilocarpine orally dissolving tablets in patients with xerostomia.
The recent outbreak of lumpy skin disease virus (LSDV) in the wetland areas of Bangladesh presents a significant concern for both animal health and regional biosecurity. Epidemiological investigations into nine major outbreaks in the wetland areas revealed distinctive clinical symptoms in affected cattle, including elevated body temperature, excessive salivation, and the presence of skin nodules. Histopathological examination unveiled larger nodules compared to previous outbreaks, along with signs of secondary infection.
Laboratório de Comportamento e Ecologia de Insetos Sociais, Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Exocrine glands are important mediators of communication in eusocial insects and the description of novel glands reflects the complex context in which these animals live. Here we revisit the head-associated glands in workers of the Neotropical termite Cornitermes cumulans through histological analysis and describe a novel gland for this caste, the intramandibular glands. This structure is located underneath the cuticle of the dorsodistal part of each mandible.
Lip defects due to lip tumor surgery need proper reconstruction to preserve their function. Traditional methods offer various options for lip repair, but each has limitations, and can lead to deformity, asymmetry, or functional impairment. This study aimed to investigate the clinical application of mandibular tongue-shaped flap reconstruction for postoperative defects following lip tumor surgery.
