The paper describes two cases of Krukenberg tumors with accompanying "arrested secretion" pattern in the endometrium. Both patients presented with a vaginal bleeding--in one case a suspicion of Krukenberg tumor was made solely on the basis of evaluation of curettage. In postmenopausal patients whose endometrium presents "arrested secretion" pattern, and who deny any progestagen therapy or substitution, the possibility of an ovarian metastatic tumor should be taken into account.
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Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations.
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Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Background: Heat shock protein 90 (Hsp90), a chaperone that regulates activity of many client proteins responsible for cellular growth, differentiation, and apoptosis, has been proposed as an important clinical and preclinical therapeutic target in a number of malignancies and autoimmune diseases, respectively. In this study, we evaluated the effects of pharmacological Hsp90 inhibition on human proinflammatory T cell responses.
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The mechanisms governing traffic across the Golgi are incompletely understood. We studied, by live-cell microscopy, the consequences of disorganizing the Aspergillus nidulans Golgi, using an extended set of fluorescent protein markers to resolve early from late cisternae. The early Golgi syntaxin SedV(Sed) (5) and the RabO(Rab) (1) regulatory GTPase play essential roles in secretion, cooperating in the ER-Golgi interface.
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Virchows Arch A Pathol Anat Histopathol
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Institute of Pathology, Universitätsklinikum Steglitz, Free University, Berlin.
In the glands of cyclic endometria, proliferative activity (PA), as revealed by expression of the Ki-67 antigen, is highest in the proliferative phase (P) and early secretory phase (S1). The PA decreases in the middle secretory phase (S2). In the stroma the PA is low during the whole cycle.
View Article and Find Full Text PDF[Endometrial gestagen effect in patients with Krukenberg tumors--report of two cases].
Patol Pol
April 1993
Zakład Patomorfologii Rozrodu Instytutu Połoznictwa i Ginekologii AM, Warszawie.
The paper describes two cases of Krukenberg tumors with accompanying "arrested secretion" pattern in the endometrium. Both patients presented with a vaginal bleeding--in one case a suspicion of Krukenberg tumor was made solely on the basis of evaluation of curettage. In postmenopausal patients whose endometrium presents "arrested secretion" pattern, and who deny any progestagen therapy or substitution, the possibility of an ovarian metastatic tumor should be taken into account.
View Article and Find Full Text PDFThe endometrium in natural and artificial luteal phases.
Hum Reprod
February 1988
Institut für Pathologie, Mannheim, FRG.
The normal human endometrium reacts precisely and sensitively to any hormonal stimulation with predictable changes. If the corpus luteum develops normally after ovulation, the progesterone secreted induces specific changes in endometrial glandular and stromal cells that can be dated by daily fine-structural alterations. With corpus luteum deficiency the endometrial differentiation is delayed and remains incomplete.
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