The total synthesis of (+)-iriciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752752 | PMC |
| http://dx.doi.org/10.1021/ol901655e | DOI Listing |
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