In an anesthesiologist's practice, except the occurrence of clinical death on the operating table a long-term complete suppression of the electrical activity of the brain may arise only from the medical staff's crude error when administering intravenous anesthetics from the unlikely breakage of the anesthesia apparatus vaporizer. However, the authors assert that such a phenomenon may develop during general anesthesia using propofol given in its usual doses. Clinical examples are given. Whether the depth of general anesthesia should be controlled by the principle of feedback, by making neurophysiological monitoring is discussed.
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BMC Microbiol
January 2025
Center for Public Health Research, Medical School of Nanjing University, Nanjing, China.
Background: Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), and can cause severe cerebral complications and even fatality in children younger than 5 years old. However, there is no specific medication for EV71 infection in clinical practice. Our previous studies had identified the 6-thioguanine (6-TG), an FDA-approved anticancer drug, as a potential antiviral agent, but its anti-EV71 activity is largely unknown, therefore, we aim to explore the antiviral effect of 6-TG on EV71.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Yale University, Department of Applied Physics and Physics, New Haven, Connecticut 06511, USA.
The selective number-dependent arbitrary phase gates form a powerful class of quantum gates, imparting arbitrarily chosen phases to the Fock states of a cavity. However, for short pulses, coherent errors limit the performance. Here, we demonstrate in theory and experiment that such errors can be completely suppressed, provided that the pulse times exceed a specific limit.
View Article and Find Full Text PDFClin Infect Dis
January 2025
ViiV Healthcare, Durham, North Carolina, USA.
JCEM Case Rep
February 2025
Clinica Medica 3, Department of Medicine-DIMED, University Hospital of Padova, Padova 35128, Italy.
Growth hormone (GH) secretion by the pituitary is regulated by stimulatory and inhibitory pathways such as growth hormone releasing hormone (GHRH) and somatostatin, respectively, being also modulated by different neurotransmitters acting at the hypothalamic/pituitary level. The pineal gland hormone melatonin regulates GH secretion in many mammals, including humans, although its role in modulating GH secretion has been debated. We describe the case of a young woman chronically taking melatonin for sleep disturbances, referring to her general practitioner for flushing that appeared just after starting melatonin intake.
View Article and Find Full Text PDFArch Endocrinol Metab
January 2025
Universidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.
Objective: Considering that the αvβ3 integrin plays an important role in tumor metastasis, this study investigated the involvement of these pathways in mediating the triiodothyronine (T3) effects on amphiregulin () expression.
Materials And Methods: We treated MCF-7 cells with T3 (10 nM) for 1 hour in the presence or absence of inhibitors for αvβ3 integrin (RGD peptide), MAPK (PD98059), PI3K (LY294002), and protein synthesis (cycloheximide [CHX]). A control group (C) received no T3 or inhibitors.
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