AI Article Synopsis
- The RBL-2H3 cell line is frequently used in research related to inflammation, allergies, and immunology, but is often mislabeled as a mast cell line even though it originates from basophils.
- There is inconsistency among different research groups regarding the characteristics and physiological responses of this cell line, leading to confusion in studies.
- The review examines the development and responses of the RBL-2H3 cell line, concluding that it shares some traits with both mast cells and basophils, but does not fully represent either type of cell.
Article Abstract
The RBL-2H3 cell line is a commonly used histamine-releasing cell line used in inflammation, allergy and immunological research. Quite commonly, it is referred to in research papers as a mast cell line, despite the fact that it is derived from basophils. There is also a lack of consistency, both between different research groups using the same cell line and with both mast cell and basophil physiology. The review follows the development of the RBL-2H3 cell line from its inception and then goes on to assess the nature of the cell line in terms of its characteristics and its response to various stimuli. The relationship of this cell line to the various mast cell subtypes and basophils is discussed and it is concluded that while the RBL-2H3 cell line shares some characteristics with both mast cells and basophils, it is not fully representative of either.
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| http://dx.doi.org/10.1007/s00011-009-0074-y | DOI Listing |
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