Evoked EMG M-responses obtained from the thenar muscle in the palm by electrical stimulation of the median nerve demonstrate a well-established smooth bipolar shape for normal healthy subjects. Kinks in this curve are observed in certain neurological disorders and preliminary work suggests their relationship to cervical spondylosis. The present work was taken up to develop an objective method for the identification of such neurological disorders for automated diagnosis by analysing the M-responses. A Fourier transform was performed using MATLAB, and features in the frequency domain were studied to distinguish healthy and smooth M-responses from ones with kinks. The features included some basic parameters like peak amplitude, peak frequency, frequency bandwidths, and areas in specified frequency segments. Ratio and deviation parameters from the above basic parameters were also studied to make 39 parameters in all. Out of these 10 came out as 'highly significant', 17 as 'significant' and the rest as insignificant, in statistical t-tests. A weighted combination of the significant parameters may allow identification of kinks with confidence.
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http://dx.doi.org/10.1007/s10867-007-9045-0 | DOI Listing |
J Neuroinflammation
January 2025
Department of Neurology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Yishan Road 600, Shanghai, 200233, China.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder worldwide, and microglia are thought to play a central role in neuroinflammatory events occurring in AD. Chemerin, an adipokine, has been implicated in inflammatory diseases and central nervous system disorders, yet its precise function on microglial response in AD remains unknown.
Methods: The APP/PS1 mice were treated with different dosages of chemerin-9 (30 and 60 µg/kg), a bioactive nonapeptide derived from chemerin, every other day for 8 weeks consecutively.
Int J Geriatr Psychiatry
January 2025
Division of Psychiatry, University College London, London, UK.
Introduction: While risk factor prevalence of individual risk factors for dementia varies between ethnic groups in New Zealand (NZ), it is not known whether the effect of these risks is the same in each group.
Methods: This retrospective cohort study identified incident cases of dementia. Cox regression models calculated the hazard ratio for dementia for each of the risk factors, after adjustment for age and sex.
Sci Rep
January 2025
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
We investigated the functional outcomes in ischemic stroke patients who underwent endotracheal intubation according to airway management (i.e., extubation success, extubation failure, primary tracheostomy) at multiple time points.
View Article and Find Full Text PDFNat Cell Biol
January 2025
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Glioblastoma (GBM) is defined by heterogeneous and resilient cell populations that closely reflect neurodevelopmental cell types. Although it is clear that GBM echoes early and immature cell states, identifying the specific developmental programmes disrupted in these tumours has been hindered by a lack of high-resolution trajectories of glial and neuronal lineages. Here we delineate the course of human astrocyte maturation to uncover discrete developmental stages and attributes mirrored by GBM.
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