Hepatocellular adenoma is a rare benign tumor of the liver. However, some complications, such as hemorrhage, rupture, and malignant transformation, have been reported previously. Surgical resection is considered to be the best choice of treatment, when adenomas are increasing in size, while resection is difficult to perform when multiple adenomas develop throughout the liver. Here, we report two cases of multiple hepatocellular adenomatosis. One patient had a history of aplastic anemia and the other had glycogen storage disease. We treated them with transcatheter arterial embolization (TAE) to prevent hemorrhage and rupture. After TAE, most parts of the adenomas showed necrotic change. These cases suggest that TAE is an effective treatment of hepatocellular adenomatosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716763 | PMC |
http://dx.doi.org/10.1007/s12072-009-9126-1 | DOI Listing |
Int J Mol Sci
September 2024
Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Diagnostics (Basel)
July 2024
Department of Pathology, NYU Langone Medical Center, New York University Grossman School of Medicine, 550 1st Avenue, New York, NY 10016, USA.
JHEP Rep
June 2024
Centre de recherche des Cordeliers, Sorbonne Université, Inserm, Université Paris Cité, team « Functional Genomics of Solid Tumors », Equipe labellisée Ligue Nationale Contre le Cancer, Labex OncoImmunology, F-75006 Paris, France.
Pediatr Dev Pathol
November 2023
Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Background: Hepatocellular adenoma (HCA) in the pediatric population is very rare and there are only limited studies, especially with molecular characterization of the tumors. Main HCA subtypes recognized in the current WHO classification include -inactivated HCA (H-HCA), inflammatory HCA (IHCA), β-catenin-activated HCA (b-HCA), and β-catenin-activated IHCA (b-IHCA) and sonic hedgehog HCA (shHCA) is reported as an emerging subtype.
Methods: Clinical history, pathological information, and molecular studies for a series of 2 cases of pediatric HCA were reviewed.
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