We studied the effects of audible and visual alarms on adherence with a recommended dosing regimen in the management of glaucoma. Forty-two patients were begun on therapy with the Travatan((R)) Dosing Aid (TDA) and randomly divided into two observation groups - one with visual and audible alarm functions turned on and the other with alarms off. Dosing information was analyzed for mean rates of adherence, missed days, and dosing at the wrong time. Twenty patients were randomized to the TDA alarm on group and 22 to the alarm off group. The rates of adherence were 87.9% and 79.7% (p = 0.02), rates of missed dosing were 7.6% and 14.4% (p = 0.03), and rates of dosing at the incorrect times were 7.1% and 9.8% (p = 0.19), respectively for alarm on versus alarm off groups. In the alarm on group, the adherence rate was significantly higher and proportion of missed dosing was significantly lower. It is still yet to be determined whether there is a relationship between adherence and progression of glaucoma.
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http://dx.doi.org/10.2147/opth.s3284 | DOI Listing |
Sci Rep
December 2024
Infettare Research Group, School of Medicine, Universidad Cooperativa de Colombia, Calle 50 No. 40-74, Medellín, Colombia.
Bacterial resistance, a global public health concern prioritized by the World Health Organization, is particularly alarming in Staphylococcus aureus and Escherichia coli. Urgently addressing this, the search for new antibiotics has turned to plant essential oils. Our study focused essential oils derived from Colombian plants Croton killipianus, Croton smithianus, Croton leptostachyus, Croton hondensis, and Croton gossypiifolius.
View Article and Find Full Text PDFEur J Pain
February 2025
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Background: Epidemiological surveys have monitored chronic non-cancer pain (CNCP) and investigated associated factors in Denmark for more than 20 years. This study aimed to analyse CNCP prevalence in the Danish population from 2000 to 2023 and its associations with mental health status and loneliness.
Methods: Population-based surveys were conducted between 2000 and 2023.
J Glob Antimicrob Resist
December 2024
Praxis Prenzlauer Berg, Berlin, Germany.
Objectives: The cell wall-less species Mycoplasma genitalium is a sexually transmitted pathogen with strong tendency to acquire resistance. Current knowledge about trends of resistance rates and differences between the risk population of men who have sex with men (MSM) and heterosexual patients as well as about circulating genotypes in both groups is limited.
Methods: Between August 2017 and December 2023, M.
Trends Cell Biol
December 2024
Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:
Over the past few years there has been an alarming burst of cancer burden worldwide. Cancer stem cells (CSCs) act as hidden devils within tumors, rendering cancer therapy a strenuous goal. Recently, the ubiquitin proteasome system (UPS) was proved to be an essential contributor to the CSC phenotype.
View Article and Find Full Text PDFHeliyon
December 2024
Accident Prevention and Assessment Division 1, National Institute of Chemical Safety, Ministry of Environment, Republic of Korea.
As the size of the chemical industry increases, chemical accidents continue to occur as the handling volume of chemicals also increases. Currently, in the case of a chemical accident, the prediction of the scope of influence mainly analyzes the scope of the impact on a single substance in the accident and does not consider the scope of the decomposition and reaction products. Nitric acid, one of the many chemical accidents, produces nitrogen dioxide, which is harmful when decomposed.
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