AI Article Synopsis
- The study aimed to assess the immune status of patients who underwent splenic embolization (SE) following traumatic injuries to guide future immunization strategies.
- Patients receiving SE were compared to those who had splenectomies (SP) and control patients with blunt abdominal trauma but no significant injuries, revealing no major differences in immune markers, apart from slightly higher suppressor T-cell levels in the SP group.
- The findings indicate that patients who had SE have immunologic profiles similar to control patients, suggesting SE is a safe treatment option, but further research with larger groups is needed to establish vaccine protocols.
Article Abstract
Background: To define the immunologic status of patients undergoing splenic embolization (SE) after traumatic injury. This information may lead to the development of immunization protocols based on scientific data.
Methods: Patients with traumatic splenic injury, treated at one level II Trauma Center were eligible for study. SE patients were compared with splenectomy (SP) patients and controls (C = blunt abdominal trauma patients with negative abdominal computed tomography scans). Clinical examination, medical survey, blood sampling, and nuclear medicine spleen scans were performed. IgM, IgG, C3 complement, complement factor B, helper T cells (CD3, CD4), suppressor T-cells (CD8), complete blood counts, and HIV status were tested. Radionuclide spleen scans were analyzed for total spleen volume, splenic defects, abnormal radionuclide uptake, and ectopic sites of tracer uptake.
Results: There were no significant differences in age, gender, or injury severity score among groups. Follow-up time was comparable (SP = 2.67 years; SE = 2.88 years). There were no significant differences in all studies measured except for higher CD8 levels in the SP group (730.1 vs. SE 452.1 vs. C 480.6; p = 0.002), although all values were within the normal range. CD3 levels showed a trend of being higher in the SP group (1709.3 vs. SE 1397.2 vs. C 1371.9), but were not statistically significant.
Conclusion: The data suggest that the immunologic profile of embolized patients is similar to controls. This supports the safe use of SE in managing the traumatically injured spleen. Larger studies examining the immune function after SE will be needed to make definitive vaccination recommendations.
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| http://dx.doi.org/10.1097/TA.0b013e3181a5e7e2 | DOI Listing |
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