Effective continuous air monitor (CAM) programs can eliminate or significantly reduce the amount of inhaled radioactive material following an accidental release. Numerous factors impact the levels of protection CAM programs provide to the workers during these releases. These factors range from those related to the capability of the CAM instrument (e.g., CAM alarm set point and length of counting intervals) to those related to CAM placement in the room relative to dispersion rates and patterns of the released material in a room. While the impact of many of these factors on alarm sensitivity has been investigated in isolation, there are no methods for holistic evaluations of CAM programs relative to radiation protection goals (RPGs) or the contribution of the factors, either individually or combined, toward limiting worker dose. In this study, worker exposure was predicted using CAM response models developed to evaluate protection levels for continuous and acute releases. Monte Carlo simulations of 10,000 releases were performed using various combinations of model parameter values, with associated uncertainty distributions, to assess the expected ability of a CAM program to meet RPGs, and, further, to assess the relative influence of each factor toward lowering worker exposure. Results showed that improvements to CAM instrument capability combined with better ventilation and CAM placement improve worker protection nonlinearly and that these improvements are critical to meet RPGs. The sensitivity analysis showed that ventilation-driven dilution had the greatest impact on exposure reduction with the selected counting interval for alarm decisions and the alarm set point as secondarily important.
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http://dx.doi.org/10.1097/HP.0b013e3181abaaa7 | DOI Listing |
Comput Methods Programs Biomed
December 2024
CenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Zhejiang, Hangzhou, China.
Background: Gastrointestinal (GI) diseases pose significant challenges for healthcare systems, largely due to the complexities involved in their detection and treatment. Despite the advancements in deep neural networks, their high computational demands hinder their practical use in clinical environments.
Objective: This study aims to address the computational inefficiencies of deep neural networks by proposing a lightweight model that integrates model compression techniques, ConvLSTM layers, and ConvNext Blocks, all optimized through Knowledge Distillation (KD).
Proteomics
January 2025
Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling and cellular phenotyping in physiological and pathological states. Here, we employed coronary artery perfusion with membrane-impermeant biotin to label and capture the surface-accessible proteome in the neo-native (intact) heart. Using quantitative proteomics, we identified 701 heart cell surfaceome accessible by the coronary artery, including receptors, cell surface enzymes, adhesion and junctional molecules.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK.
Shells of Pd and Pt were synthesized on Au nanoparticles by electrodeposition, leading to controllable size and optical properties. This approach yielded core-shell structures with good homogeneity in size after the optimization of electrochemical parameters such as deposition current and charge transfer, as well as nanoparticle surface treatment. Dark field scattering microscopy and spectroscopy were used to track changes in the optical response of individual particles during deposition.
View Article and Find Full Text PDFJ Prosthodont
January 2025
Department of Prosthodontics and Research Institute of Oral Science, College of Dentistry, Gangneung-Wonju National University, Gangneung, South Korea.
Purpose: This study aimed to investigate the effect of crystallization and finish line curvature on the integrity of lithium disilicate crowns fabricated by using partially crystallized (P) and fully crystallized (F) blocks.
Materials And Methods: Forty-eight lithium disilicate crowns were fabricated based on the designated lithium disilicate blocks and finish line curvatures. The specimens were divided into four groups (n = 12 each): P block with a curved finish line (PC), P block with a straight finish line (PS), F block with a curved finish line (FC), and F block with a straight finish line (FS).
Implement Sci Commun
January 2025
Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA.
Background: Approximately one in six children has a disability, and effective, evidence-based rehabilitation can ameliorate the impact of these conditions over the lifespan. However, implementing interventions in real-world settings remains a challenge. This scoping review aimed to summarize the characteristics, implementation strategies, and outcomes of implementation studies in pediatric rehabilitation.
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