In chronic brucellosis due to Brucella melitensis, cell-mediated responses were transiently depressed in comparison to antibody responses. To elucidate the mechanism of immunosuppression, we examined the role of transforming growth factor beta (TGF-beta) in cellular immune responses of 20 patients with chronic brucellosis. Circulating TGF-beta1 level was markedly elevated is sera of patients with confirmed brucellosis as compared with those from Brucella-negative healthy control subjects. In contrast, a 2-fold increase of TGF-beta1 production was demonstrated in patients peripheral blood mononuclear cells (PBMC)-stimulated with Brucella cell extract (BCE) antigen. The increased production of TGF-beta1 protein was dually associated with enhanced expression of TGF-beta mRNA in patients PBMC and diminished lymphoproliferative responses to BCE. A causal relationship between increased TGF-beta1 production and depressed lymphoproliferative responses was demonstrated by treatment of proliferating PBMC with a neutralizing antibody to TGF-beta1 where the lymphocytes function has been restored. These results suggest that the increased activity of TGF-beta1 may underlie the depressed function of T cell responses with consequent prolongation of disease course in patients with chronic brucellosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.micinf.2009.08.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Double trouble: The intersection of neurobrucellosis and systemic lupus erythematosus in a 24-year-old female.
eNeurologicalSci
December 2024
Radiological Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001 Babylon, Iraq.
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs, while brucellosis is a zoonotic infection prevalent in endemic areas. Neurobrucellosis, a severe complication of brucellosis, can mimic or coexist with autoimmune conditions like SLE, complicating diagnosis and treatment. This case report highlights the diagnostic challenges and management strategies for such overlapping diseases.
View Article and Find Full Text PDF[The Diagnostic Value of Serum sTREM-1, Presepsin and IFN-Gamma Levels in Brucellosis Patients].
Mikrobiyol Bul
October 2024
Atatürk University Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Türkiye.
Brucellosis is a zoonotic disease that causes high rates of morbidity and mortality due to difficulties in diagnosis and inadequate treatment. The purpose of this study was to assess the diagnostic significance of presepsin, trigger receptor expressed on soluble myeloid cells-1 (sTREM-1), and interferon-gamma (IFN-gamma) levels in patients with brucellosis. One hundred twenty-one brucellosis patients aged 18 or over and 39 healthy volunteers were included in this prospective study.
View Article and Find Full Text PDFUnraveling a Complex Case: Brucellosis Manifesting as Fever of Unknown Origin, Septic Ankle Arthritis, and Iliacus Abscess.
Cureus
November 2024
Internal Medicine, Al-Saudi Hospital, Amman, JOR.
Brucellosis is an infectious disease caused by bacteria of the genus , predominantly affecting livestock and humans through contact or consumption. It is a major public health challenge, particularly in developing countries. Symptoms can be mild to severe, making diagnosis difficult and often resulting in more chronic problems if those issues are not addressed.
View Article and Find Full Text PDFIdentification of Brucella RS15060 as a novel type IV secretion system effector associated with bacterial virulence.
Vet Res
December 2024
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, China.
Brucella is an intracellular parasitic pathogen that causes the worldwide zoonotic disease brucellosis. The type IV secretion system (T4SS) is utilized to secrete various effectors to help Brucella form Brucella-containing vacuoles within the cell and accomplish intracellular trafficking and replication. Brucella has fewer recognized effector proteins than other intracellular parasites in the Proteobacteria, indicating that Brucella may contain a large number of unidentified effector proteins.
View Article and Find Full Text PDFWhat Could Lead to the Production of Anti-Rheumatoid Antibodies in Patients with Brucellosis Spondylodiscitis: Possible Causes.
Med J Islam Repub Iran
August 2024
Department of Clinical Disciplines, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Background: High titers of specific antibodies to cyclic citrulline peptide (ACCP) are often present in the serum of patients with rheumatoid arthritis (RA) and, together with rheumatoid factor (RF), are a diagnostic marker of RA. Brucellosis is a zoonotic infection in which osteoarticular involvement occurs in 10-85% of patients. RF in brucellosis patients is significantly higher than in healthy people.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!