Objective: To study the dissolution behavior, the release mechanism and the stability of nanodispersion system of aglycones with PVP.

Methods: The nanodispersion system of polyvinylpyrrolidone (PVP)/naringenin-hesperetin was prepared using the solvent evaporation method. The chemical stability (compatibility) of naringenin and hesperetin in the prepared dispersions was studied under accelerated conditions for 3 months. The evaluation of physical stability was performed by X-ray diffraction analysis (XRD) and by comparing the dissolution profile before and after storage at high temperature and moisture (40 masculineC, RH 75%).

Results: The dissolution rate of naringenin and hesperetin released was dramatically increased in the nanodispersion system of PVP/naringenin-hesperetin (80/20, w/w). The release mechanism of both flavanone aglycones was better described by the diffusion model (Higuchi model). Also it was found that the rate-limiting step that controlled the release of naringenin and hesperetin in the nanodispersion system was dissolution of the carrier (PVP).

Conclusions: During accelerated degradation analysis, for 3 months at high temperature and moisture, PVP nanodispersion system showed enhanced chemical compatibility and physical stability. The physical evaluation (obtained from XRD analysis) of PVP/naringenin-hesperetin (80/20, w/w) in the selected storage conditions did not show any crystallization of flavanone aglycones in the PVP nanodispersion system or any change in their release profile.

Download full-text PDF

Source
http://dx.doi.org/10.1080/03639040903140589DOI Listing

Publication Analysis

Top Keywords

nanodispersion system
24
naringenin hesperetin
16
flavanone aglycones
12
dissolution rate
8
release mechanism
8
physical stability
8
high temperature
8
temperature moisture
8
pvp/naringenin-hesperetin 80/20
8
80/20 w/w
8

Similar Publications

Rivaroxaban is an anticoagulant for avoidance and therapy of thromboembolic disorders. Unfortunately, oral bioavailability of rivaroxaban is compromised with dose increments. Accordingly, the aim was to test nano-vesicular lipid systems for improved oral anticoagulation activity of rivaroxaban.

View Article and Find Full Text PDF
Article Synopsis
  • The study addresses cardiac arrhythmias, a condition requiring long-term management with medications like diltiazem hydrochloride, which faces limitations in traditional administration methods due to absorption challenges.
  • Researchers developed a transdermal patch using solid lipid nanoparticles (SLNs) to enhance the drug's skin permeability and bioavailability, employing a solvent diffusion technique for SLN preparation.
  • Results showed that the formulated patch had a good drug release profile (70.7% over 24 hours), a high drug content of 89.37%, and an optimal surface pH close to that of human skin, making it a promising delivery method for diltiazem.
View Article and Find Full Text PDF

Self-assembled lipid nanoparticles (LNPs) are essential nanocarriers for drug delivery. Functionalization of LNPs with ionizable lipids creates pH-responsive nanoparticles that change structures under varying pH conditions, enabling pH-triggered drug release. Typically, bicontinuous cubic phase nanoparticles (Cubosomes) and lamellar structured vesicles (Liposomes) differ in lipid packing statuses, affecting drug release and cellular uptake.

View Article and Find Full Text PDF

The low and erratic oral absorption of sulpiride (SUL) a dopaminergic receptor antagonist, and its P-glycoprotein efflux in the gastrointestinal tract restricted its oral route for central nervous system disorders. An intranasal formulation was formulated based on nanostructured lipid carrier to tackle these obstacles and deliver SUL directly to the brain. Sulipride-loaded nanostructured lipid carrier (SUL-NLC) was prepared using compritol888 ATO and different types of liquid lipids and emulsifiers.

View Article and Find Full Text PDF

The multibiocomponent hybrid alginate hydrogels based on brown and sea algae, containing 100 % ingredients of natural origin were prepared by ionic crosslinking reaction of a polymeric matrix with lipid nanodispersion. To the best of the Authors' knowledge such multicomponent biobased hydrogel of promising medical and cosmetical applications for the first time was obtained in the environment of flower water, received earlier as a waste by-product from various chemical processes. An innovative hybrid alginate hydrogel that is completely biodegradable and eco-friendly was obtained following waterless and upcycling trends that are in line with the principles of sustainable development.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!