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Muscle Weakness - new genetic defect transmitted to Polish Holstein-Friesian cattle.
Pol J Vet Sci
December 2024
University of Warmia and Mazury, Department of Animal Genetics, 10-719 Olsztyn, Oczapowskiego 5. Email: Tel.: +48/89/5234714.
The aim of the study was to find out whether carriers of new genetic defect Muscle Weakness (MW) occur in the population of Polish Holstein-Friesian bulls. Fifty bulls were included in the analysis. Bulls were selected as having in the pedigree known carrier of MW.
View Article and Find Full Text PDFMachine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4.
Front Biosci (Landmark Ed)
November 2024
Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China.
Background: Aneuploidy is crucial yet under-explored in cancer pathogenesis. Specifically, the involvement of brain expressed X-linked gene 4 () in microtubule formation has been identified as a potential aneuploidy mechanism. Nevertheless, 's comprehensive impact on aneuploidy incidence across different cancer types remains unexplored.
View Article and Find Full Text PDFPrognostic Value of / Status for Overall Survival in First-Line Monoimmunotherapy and Chemoimmunotherapy Treated Patients With Nonsquamous NSCLC in the Netherlands: A Brief Report.
JTO Clin Res Rep
December 2024
Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Introduction: Programmed death-ligand 1 (PD-L1) is the main predictive biomarker used to identify patients with NSCLC who are eligible for treatment with immune checkpoint inhibitors. Despite its utility, the predictive capacity of PD-L1 is limited, necessitating the exploration of supplementary predictive biomarkers. In this report, we describe the prognostic value of / mutation status for overall survival (OS) in patients with NSCLC treated with first-line immunotherapy or combined chemoimmunotherapy.
View Article and Find Full Text PDFAnalysis of genetic instability induced by radon exposure in iron mine processing workers in Shandong Province, Northern China.
Front Public Health
December 2024
School of Preventive Medicine, Shandong First Medical University (Institute of Radiation Medicine, Shandong Academy of Medical Sciences), Jinan, Shandong, China.
Background: Radon, a colorless and odorless radioactive gas, poses serious health risks. It is the second leading cause of lung cancer and notably increases lung cancer risk in smokers. Although previous epidemiological studies have mainly examined lung cancer rates in miners, the effects of radon on genomic stability and its molecular mechanisms are not well understood.
View Article and Find Full Text PDFCOVID-19 outbreaks caused by different SARS-CoV-2 variants: a descriptive, comparative study from China.
Front Public Health
December 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Objectives: To understand the epidemic characteristics of various SARS-CoV-2 variants, we mainly focus on analyzing general epidemic profiles, viral mutation, and evolution of COVID-19 outbreaks caused by different SARS-CoV-2 variants of concern (VOCs) in China as of August 2022.
Methods: We systematically sorted out the general epidemic profiles of outbreaks caused by various SARS-CoV-2 VOCs in China, compared the differences of outbreaks caused by Delta and Omicron VOCs, and analyzed the mutational changes of subvariants between the same outbreak and different outbreaks.
Findings: By 15 August 2022, a total of 2, 33, and 124 COVID-19 outbreaks caused by Alpha, Delta, and Omicron VOCs, respectively, were reported in different regions of China.
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