The objective of the present study was to investigate the effect of the saponin fraction from Clematis chinensis Osbeck roots (SFC) on an osteoarthritis model in rats and to explore its underlying mechanisms. Osteoarthritis was induced by intraarticular injection of monosodium iodoacetate (MIA) into knee joints of rats, and SFC and diclofenac were orally administered once a day for 28 consecutive days. Joint swelling, macroscopic observation, histological assessment and proteoglycan (PG) degradation were examined. In vitro, cultured rabbit chondrocytes were stimulated with MIA and sodium nitroprusside (SNP), respectively. The effects of SFC on MIA- and SNP-induced chondrocyte injury were examined by MTT assay. It was shown that SFC (50, 100, 200 mg/kg) dose-dependently reduced cartilage injury and PG degradation induced by MIA. Diclofenac (4 mg/kg) only slightly alleviated cartilage injury and PG degradation. SFC also prevented SNP- or MIA-induced rabbit chondrocyte impairment. These results indicate that SFC is effective in ameliorating joint destruction and cartilage erosion in MIA-induced osteoarthritic in rats, and the mechanisms of action for protecting articular cartilage are through preventing extracellular matrix degradation and chondrocyte injury.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ptr.2977 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Non-saponin from maintains blood-brain barrier integrity by inhibiting NF-κB and p38 MAP kinase signaling pathways to prevent the progression of experimental autoimmune encephalomyelitis.
J Ginseng Res
January 2025
Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Background: The non-saponin (NS) fraction is an important active component of with multifunctional pharmacological activities including neuroprotective, immune regulatory, anti-inflammatory, and antioxidant effects. However, the effects of NSs on multiple sclerosis (MS), a chronic and autoimmune demyelinating disorder, have not yet been demonstrated.
Purpose: and Methods: The goal of the present study was to demonstrate the pharmacological actions of NSs on movement dysfunctions and the related mechanisms of action using an experimental autoimmune encephalomyelitis (EAE) mouse model of MS.
Aloe arborescens Standardized Glycosidic Fraction Suppresses Hepatocarcinoma by Modulating TIMP1, MMP9 Genes Expression, and Inflammation/Ki67/TGFβ1 Pathway.
Phytother Res
December 2024
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.
(1) Background and aim: Aloe arborescens Mill. (A. arborescens) is one of the most widely distributed species in the genus Aloe and has garnered widespread recognition for its anticancer properties.
View Article and Find Full Text PDFA review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity.
Biomed Eng Online
December 2024
Department of Stem Cells Technology and Tissue Regeneration, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, 15614, Iran.
Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This can lead to a range of cardiac complications, including heart failure, arrhythmias, myocardial dysfunction, pericardial complications, and vascular toxicity. Strategies to mitigate chemotherapy-induced cardiotoxicity may include the use of cardioprotective agents (e.
View Article and Find Full Text PDF[Comparative study on activation of latent HSV-1 induced "Shanghuo" by two different properties of traditional Chinese medicines].
Zhongguo Zhong Yao Za Zhi
October 2024
Guangdong Engineering Research Center for Disease Susceptibility and Traditional Chinese Medicine, Jinan University Guangzhou 510632, China Guangzhou Key Laboratory of Disease Susceptibility and Traditional Chinese Medicine Prevention and Treatment, Jinan University Guangzhou 510632, China Guangdong, Hong Kong and Macao Joint Laboratory of Universities, Guangdong Province, Jinan University Guangzhou 510632, China Institute of Traditional Chinese Medicine and Natural Medicines, Jinan University Guangzhou 510632, China.
Article Synopsis
- Traditional Chinese Medicine (TCM) describes "Shanghuo" as a symptom arising from Yin-Yang imbalance, which can be triggered by consuming hot-natured herbs.
- In a mouse model of "Shanghuo," researchers found that Ginseng Radix et Rhizoma (hot natured) activated HSV-1 and induced "Shanghuo," while Lycii Fructus (neutral) did not.
- Different fractions of Ginseng were tested, revealing that the saponin-rich fractions, particularly GS3, were responsible for inducing HSV-1 reactivation, highlighting the link between TCM herb properties and HSV-1 behavior.
From an Invasive Weed to an Insecticidal Agent: Exploring the Potential of in Insect Management Strategies-A Review.
Int J Mol Sci
November 2024
Department of Agronomy, Bihar Agricultural University, Sabour, Bhagalpur 813210, Bihar, India.
Article Synopsis
- The text discusses the wide range of chemical constituents in weed, including alkaloids and terpenoids, which enhance its medicinal and pesticidal properties.
- It highlights the insecticidal activity of essential oils extracted from the plant, noting variations in effectiveness due to seasonal changes and differences in plant parts.
- The review concludes that integrating traditional knowledge with modern research can help utilize this plant as a natural insecticide, emphasizing the need for further studies on its bioactive compounds.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!