Methanol toxicity is still a relatively common poisoning worldwide. Exposure typically occurs through ingestion, but there is potential for occupational inhalational exposures as well. People with potential exposure to methanol in any form need to wear the appropriate personal protective equipment, and they need to be familiar with proper detection methods. Medical professionals need to understand the metabolism of methanol and why knowledge of this metabolism is important for the diagnosis and management of this unique poison. Several methods of treatment exist for methanol toxicity. Through development of an under-standing of the pathophysiology behind the toxin, the appropriate measures can be taken.
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http://dx.doi.org/10.1007/BF03161229 | DOI Listing |
Unlabelled: is a high-priority organism for the development of new antibacterial treatments. We found that the antimalarial medication mefloquine (MFQ) permeabilized the bacterial cell membrane of , decreased membrane fluidity, and caused physical injury to the membrane. MFQ also maintained activity across different pH conditions (PH range 5-8).
View Article and Find Full Text PDFHeliyon
January 2025
Department of Chemical Engineering, Bangladesh University of Engineering and Technology, Dhaka, 1000, Bangladesh.
Synthetic antidiabetic drugs are often associated with various adverse side effects, including hypoglycemia, nausea, gastrointestinal disturbances, headaches, and even liver damage. In contrast, plant-derived natural antidiabetic bioactive compounds typically exhibit lower toxicity and fewer side effects and have been reported to aid effectively in diabetes management. These plant extracts regulate diabetes by restoring pancreatic function, enhancing insulin secretion, inhibiting intestinal glucose absorption, and facilitating insulin dependent metabolism.
View Article and Find Full Text PDFMolecules
January 2025
Department of Food Plant Chemistry and Processing, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.
In this study, the effectiveness of three choline chloride (ChCl)-based deep eutectic solvents (DESs) formed using malonic acid (MalA), glycerol (Gly), and glucose (Glu) as hydrogen bond donors and two conventional solvents (50% methanol and 50% ethanol) for ultrasonic-assisted extraction (UAE) of antioxidant compounds from four herbs (chamomile, lemon balm, nettle, and spearmint) were estimated. The antioxidant capacity (AC) of the obtained herb extracts was determined by the modified 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and cupric reducing antioxidant capacity (CUPRAC) methods. Profiles of phenolic acids, flavonoid aglycones, and flavonoid glycosides in the green and conventional herb extracts were quantitatively analyzed using ultra-performance liquid chromatography (UPLC).
View Article and Find Full Text PDFLife (Basel)
December 2024
Interdisciplinary Research Group at Sechium edule in Mexico, A.C., Agustin Melgar 10, Col. Niños Héroes, Texcoco 56160, Estado de México, Mexico.
The genus P. Br. (Cucurbitaceae) includes ten species, two of which are edible.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Faculty of Electrical, Electronic, Computer and Control Engineering, Lodz University of Technology, 18. Stefanowskiego Str., 90-924 Lodz, Poland.
Toxic materials are a threat in workplaces and the environment, as well as households. In them, gaseous substances are included, especially ones without any colour or fragrance, due to their non-detectability with the human senses. In this article, an attempt was made to find a solution for its detection in various conditions with the use of intelligent textiles.
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