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Diagnostic accuracy of folate receptor-positive circulating tumor cells in differentiating between benign and malignant pulmonary nodules.
Transl Cancer Res
December 2024
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Background: Currently, traditional blood biomarkers such as neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA) etc. are mostly elevated in the late stage of tumour, and patients have already lost the chance of tumour eradication when the relevant indexes are found to be elevated. Therefore, there is a need for blood biomarkers with higher sensitivity, better specificity, and better accessibility.
View Article and Find Full Text PDFObjective: To investigate the effect of Brucea javanica Oil combined with chemotherapy on serum cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), immune mechanism, and prognosis in patients with lung cancer and provide a reference for its clinical diagnosis and treatment.
Methods: This study involved 112 lung cancer patients from June 2019 to January 2022 at Shanghai Guanghua Hospital. They were randomly divided into two groups: control (chemotherapy only) and observation (chemotherapy + Brucea javanica oil emulsion).
Abnormal expression of miR-668-3p in non-small cell lung cancer patients and its correlation with serum-related tumor markers.
J Cardiothorac Surg
January 2025
Department of Oncology, The 969th Hospital of the PLA joint Logistics Support Force, No. 57, Aimin Street, Xincheng District, Hohhot City, Inner Mongolia Autonomous Region, 010051, China.
Background: The accuracy and reliability of identified biomarkers in differentiating early non-small cell lung cancer (NSCLC) remain suboptimal, thereby impeding the timely detection of NSCLC.The objective of this research is to examine the expression level and diagnostic utility of miR-668-3p in individuals with NSCLC, along with its effectiveness and predictive capacity in the combined diagnosis of early-stage NSCLC using serum markers.
Methods: The research included 117 NSCLC patients and 101 pulmonary nodule patients (controls).
The establishment of PD-1 inhibitor treatment prognosis model based on dynamic changes of peripheral blood indexes in patients with advanced lung squamous cell carcinoma.
Front Oncol
December 2024
Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Article Synopsis
- Patients with lung squamous cell carcinoma (LUSC) show limited benefits from targeted therapies, but immunotherapy, particularly PD-1 inhibitors, has emerged as a potential treatment option, although responses vary among individuals.
- A study analyzed data from 212 LUSC patients undergoing PD-1 combination therapy, focusing on making sense of various hematological indices at different treatment stages to find predictors for treatment outcomes and survival analysis.
- Findings revealed specific hematological markers (like SCC and NSE levels) significantly correlate with progression-free survival (PFS) and overall survival (OS), suggesting their potential as independent indicators for predicting patient prognosis in LUSC.
Impedimetric Biosensors for the Quantification of Serum Biomarkers for Early Detection of Lung Cancer.
Biosensors (Basel)
December 2024
Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, Bedfordshire MK43 0AL, UK.
Lung cancer is the most common type of cancer diagnosed worldwide and is also among the most fatal. Early detection, before symptoms become evident, is fundamental for patients' survival. Therefore, several lung cancer biomarkers have been proposed to enable a prompt diagnosis, including neuron-specific enolase (NSE) and carcinoembryonic antigen (CEA).
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