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Beta-human chorionic gonadotropin, carbohydrate antigen 19-9, cancer antigen 125, and carcinoembryonic antigen as prognostic and predictive biological markers in bladder cancer.
Front Oncol
December 2024
Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea.
Introduction: We evaluated the prognostic potential of the Beta-human chorionic gonadotropin (β-hCG), Carbohydrate Antigen 19-9 (CA19-9), Cancer Antigen 125 (CA125), and Carcinoembryonic Antigen (CEA) tumor markers for bladder cancer.
Methods: We analyzed the records of 369 patients who underwent radical cystectomy for urothelial cancer (UC) between October 2012 until December 2019. Levels of CA19-9, CA125, CEA, and β-hCG before radical cystectomy were measured in all patient samples, and serum biomarker cutoff values were used as normal and elevated values.
Exploring Early Kinetic Profiles of CEA, ctDNA and cfDNA in Patients With RAS-/BRAF-Mutated Metastatic Colorectal Cancer.
Clin Colorectal Cancer
December 2024
Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; Faculty of Technology, Natural Sciences and Maritime Sciences, University of South-Eastern Norway, Bø in Telemark, Norway.
Article Synopsis
- Early identification of patients with metastatic colorectal cancer (mCRC) who may not benefit from first-line chemotherapy could guide the timely use of second-line treatments, potentially improving outcomes.
- The study analyzed the relationship between changes in carcinoembryonic antigen (CEA), circulating cell-free DNA (cfDNA), and circulating tumor DNA (ctDNA) during chemotherapy, finding that early ctDNA changes are more predictive of treatment response and survival outcomes than CEA.
- Results indicated that lack of a strong molecular response in ctDNA by the first evaluation was linked to shorter progression-free survival (PFS) and overall survival (OS), highlighting ctDNA's potential as a valuable biomarker in monitoring mCRC treatment.
Prognostic significance of CEA reduction rate in patients with abnormally high preoperative CEA levels who underwent surgery for lung cancer.
J Cardiothorac Surg
December 2024
Department of Thoracic Surgery, Kochi Medical School, Kohasu, Oko-Cho, Nankoku-City, Kochi, 783-8505, Japan.
Background: The aim of this research was to investigates the prognostic importance of change in carcinoembryonic antigen (CEA) levels (particularly abnormal high concentration) in patients with non-small cell lung cancer (NSCLC) between before and after surgery.
Methods: The study involved 68 patients with NSCLC ( preoperative CEA value ≥ 10 ng/ml) who received curative operation from 2012 to 2020. Preoperative and postoperative serum CEA levels, CEA reduction, and other clinicopathological factors were determined on medical records.
MRI-based radiomic nomogram for predicting disease-free survival in patients with locally advanced rectal cancer.
Abdom Radiol (NY)
December 2024
Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.
Purpose: Individual prognosis assessment is of paramount importance for treatment decision-making and active surveillance in cancer patients. We aimed to propose a radiomic model based on pre- and post-therapy MRI features for predicting disease-free survival (DFS) in locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy (nCRT) and subsequent surgical resection.
Methods: This retrospective study included a total of 126 LARC patients, which were randomly assigned to a training set (n = 84) and a validation set (n = 42).
Significance of the modified global leadership initiative on malnutrition (GLIM) criteria malcondition for patients with biliary tract cancer.
Surg Today
December 2024
Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Purpose: This study investigated the significance of the Global Leadership Initiative on Malnutrition (GLIM) for patients with resected biliary tract cancers.
Methods: The subjects of this retrospective analysis were 114 patients who underwent radical surgery for cholangiocarcinoma between 2018 and 2023. We analyzed both handgrip force and skeletal muscle area and classified patients as having GLIM malnutrition or modified GLIM malcondition.
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