This study proposes new developmental stages for Callithrix jacchus, using K-Means algorithm and an artificial neural network-self-organising maps (SOM) as computational tools, based on weight and age. Eight developmental stages are proposed: Infant I, II and III, Juvenile I and II, Sub adult, Young adult and Older adult. This classification is consistent with the first appearance of several behavioural and physiological characteristics and thus may have generality in defining critical developmental periods. It also reveals differences in male and female development and establishes a stage for the onset of the final adult life cycle. This classification is also important to understanding the biology of the ontogenetic development of common marmosets, providing new insights for the management and care of captive animals and improving age estimate indicators when specimens are captured in long term monitoring of free ranging groups.
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http://dx.doi.org/10.1016/j.compbiomed.2009.05.009 | DOI Listing |
J Forensic Odontostomatol
December 2024
Faculty of Dentistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
This study aims to compare the accuracy of Demirjian's and Cameriere's methods in determining adult age at the 18-year threshold using mandibular third molars in the Thai population. Panoramic radiograph images of 504 healthy subjects aged between 14 and 23 years were retrospectively collected. The developmental stages of mandibular third molars were evaluated using Demirjian's method, while the maturity index of mandibular third molars (I3M) was assessed using Cameriere's method.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
Background: Circadian rhythm disorder is not only a characteristic of neurodegenerative diseases but may participate in driving the pathological development in early stages of these diseases. Transactive response DNA-binding protein of 43 kDa (TDP-43) knockdown and its pathological aggregation are associated with severe neurodegenerative diseases such as amyotrophic lateral sclerosis.
Methods: C57BL/6 mice were sleep deprived and sarcrificed at ZT0, ZT6, ZT12, and ZT18 and detected by Western blots.
Alzheimers Dement
December 2024
Purdue University, West Lafayette, IN, USA.
Background: Exposure to environmental chemicals such as lead (Pb) during vulnerable developmental periods and even in adult stage can result in adverse health outcomes later in life. Human cohort studies have demonstrated associations between Pb exposure and Alzheimer's Disease (AD) onset in later life which were further corroborated by findings from animal studies. The molecular pathway linking Pb exposure and increased AD risk, however, remains elusive.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Developmental and Educational Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Background: The importance of coincidence of cognitive complaints between participants without objective impairment and their informants in predicting progression remains unclear (Nosheny et al, 2022). Our objective was to determine whether agreement in dyadic reporting at baseline can predict survival time to progression to MCI or dementia.
Method: A sample of 145 participants from the CompAS Study was included in a survival analysis.
Alzheimers Dement
December 2024
Massachusetts General Hospital, Boston, MA, USA.
Background: In cognitively unimpaired (CU) older adults, the presence of a subjective cognitive decline (SCD) combined with evidence of abnormal b-amyloid (Ab) is proposed as stage 2 of Alzheimer's disease (AD) by the NIA-AA framework (Jack et al., 2018). However, the associations found between SCD and preclinical AD are inconsistent across studies, highlighting the importance of better understanding which specific SCD features are associated with either Ab or tau burden.
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