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Reproductive hormone replacement alters sleep in mice. | LitMetric

Reproductive hormone replacement alters sleep in mice.

Neurosci Lett

Department of Anatomy and Neurobiology, Morehouse School of Medicine, 720 Westview Dr., S.W. MRC F14, Atlanta, GA 30310-1495, USA.

Published: October 2009

AI Article Synopsis

  • Several studies indicate that reproductive hormones affect sleep patterns, but this research is the first to investigate their impact on sleep in adult mice.
  • In the experiment, adult male and female mice had their gonads removed and were given hormone replacements: testosterone for males and estrogen for females, while their sleep was monitored.
  • Results showed that estrogen reduced NREM sleep in females, while testosterone increased it in males; however, both hormone-treated groups had similar recovery sleep after being sleep-deprived, suggesting these hormones influence baseline sleep but not the recovery process.

Article Abstract

Several studies have reported that reproductive hormones can alter baseline sleep-wake states, however, no studies in mice have examined whether reproductive hormone replacement in adult females and males influences sleep. In this study, we determined whether androgen replacement in males and estrogen replacement in females alter sleep-wake amount and sleep rebound after extended wakefulness. The gonads from adult male and female C57BL/6J mice were removed and animals were implanted with continuous release hormone or placebo pellets. Male mice received testosterone and females received 17beta-estradiol. Recording electrodes were implanted to monitor sleep-wake states under baseline conditions and in response to 6h of sleep deprivation. During baseline recording estradiol-treated females exhibited a reduction in NREM sleep amount that was predominant during the dark phase. Testosterone-treated males conversely, exhibited an increase in NREM sleep amount. After sleep deprivation, hormone-treated males and females exhibited similar amounts of recovery sleep however males exhibited slightly more sleep than placebo-treated controls. The results of these experiments demonstrate that the androgens and estrogens are primarily responsible for sex differences in baseline sleep-wake amount but do not have substantial effects on homeostatic sleep rebound after extended wakefulness.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749224PMC
http://dx.doi.org/10.1016/j.neulet.2009.07.081DOI Listing

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