Antibacterial bioassay-guided fractionation of two American mushroom species, Jahnoporus hirtus and Albatrellus flettii, led to the isolation and identification of their major antibacterial constituents: 3,11-dioxolanosta-8,24( Z)-diene-26-oic acid (1) from J. hirtus and confluentin (2), grifolin (3), and neogrifolin (4) from A. flettii. Compound 1 is a new lanostane-type triterpene. All purified compounds were evaluated for their ability to inhibit the growth of Bacillus cereus and Enterococcus faecalis using standard MIC assays. Compounds 1- 4 demonstrated MIC values of 40, 20, 10, and 20 microg/mL, respectively, against B. cereus and MIC values of 32, 1.0, 0.5, and 0.5 microg/mL, respectively, against E. faecalis. Thus, one novel compound and three others were shown to possess antimicrobial activities against these gram-positive bacteria employed as surrogates for more virulent and dangerous pathogens.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-0029-1186001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Study of the Anti-MYC Potential of Lanostane-Type Triterpenes.
ACS Omega
December 2024
Department of Organic and Inorganic Chemistry, Science Center, Federal University of Ceará, Fortaleza, CE 60455-760, Brazil.
One of the most investigated molecular targets for anticancer therapy is the proto-oncogene , which is amplified and thus overexpressed in many types of cancer. Due to its structural characteristics, developing inhibitors for the target has proven to be challenging. In this study, the anti-MYC potential of lanostane-type triterpenes was investigated for the first time, using computational approaches that involved ensemble docking, prediction of structural properties and pharmacokinetic parameters, molecular dynamics (MD), and binding energy calculation using the molecular mechanics-generalized born surface area (MM-GBSA) method.
View Article and Find Full Text PDFResearch progress on chemical diversity of saponins in .
Chin Herb Med
October 2024
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Saponins, the major bioactive components of C. A. Mey.
View Article and Find Full Text PDFCE9A215 (inotodiol), a lanostane-type oxysterol, mitigates LPS-induced sepsis through multifaceted mechanisms.
Eur J Pharmacol
October 2024
CARBOEXPERT Inc, Daejeon, 34134, Republic of Korea; Department of Food Science and Technology, Chungnam National University, Daejeon, 34134, Republic of Korea. Electronic address:
Article Synopsis
- Dysregulated immune responses during infections can cause sepsis, leading to multiple organ dysfunction and highlighting the need for new treatment approaches.
- CE9A215 (inotodiol), a compound derived from fungi, has shown potential anti-inflammatory effects by reducing pro-inflammatory cytokines in both cell cultures and animal models.
- The study found that CE9A215 improved survival in mice with sepsis while promoting the clearance of harmful lipopolysaccharides by enhancing specific proteins associated with lipid transport, suggesting its potential as a new therapy for sepsis.
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis.
Arch Pharm Res
March 2024
School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Korea.
Gymnopilus orientispectabilis, also known as "big laughter mushroom," is a hallucinogenic poisonous mushroom that causes excessive laughter upon ingestion. From the fruiting bodies of G. orientispectabilis, eight lanostane-type triterpenoids (1-8), including seven novel compounds: gymnojunols A-G (2-8), were isolated.
View Article and Find Full Text PDFLanostane triterpenoids from the fruiting bodies of Ganoderma amboinense.
Phytochemistry
February 2024
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China. Electronic address:
Article Synopsis
- Ganoderma mushrooms are special because they contain unique chemicals called lanostane-type triterpenoids.
- Researchers studied the Ganoderma amboinense mushrooms and discovered twelve new lanostane triterpenoids that were not known before.
- Some of these new compounds can help prevent certain health issues, like high blood sugar and inflammation, with different strengths in their abilities.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!