AI Article Synopsis
- The study aimed to analyze the chemical compounds in the fruit of Alpinia oxyphylla and their effects on cancer cell lines.
- Eight compounds were extracted and their structures were confirmed using various scientific methods; specifically, the cytotoxic effects of five were tested against three different cancer cell lines.
- The research concluded that certain compounds from the fruit had not been previously identified in this genus, but showed no cytotoxic effects on the tested cancer cell lines at the concentration used.
Article Abstract
Objective: To study the chemical constituents in fruit of Alpinia oxyphylla and their cytotoxicities on cancer cell lines.
Method: Compounds were isolated and purified by various column chromatographic methods. Their structures were determined by physico-chemical properties and spectral analyses. Compound cytotoxicity was assessed by the sulforhodamine B (SRB) assay.
Result: Eight compounds were obtained from Me2CO-H2O (70%) extract of the fruit of A. oxyphylla and their structures were identified as: (9E)-humulene-2, 3; 6, 7-diepoxide (1), 3(12), 7(13), 9(E)-humulatriene-2, 6-diol (2), (-)-oplopanone (3), yakuchinone A (4), yakuchinone B (5), tectochrysin (6), isovanillin (7), (2E, 4E)-6-hydroxy-2, 6-dimethylhepta-2, 4-dienal (8), and the cytotoxicities of compounds 1, 3-5 on cancer cell lines, A549, HT-29 and SGC-7901, were also investigated.
Conclusion: Compounds 1-3, 7, 8 were isolated for the first time from this genus and compounds 1, 3-5 exhibited no cytotoxicity against three cancer cell lines at a concentration of 10 mg x L(-1).
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