The performance of the protein structure prediction server pro-sp3-TASSER in CASP8 is described. Compared to CASP7, the major improvement in prediction is in the quality of input models to TASSER. These improvements are due to the PRO-SP(3) threading method, the improved quality of contact predictions provided by TASSER_2.0, multiple short TASSER simulations for building the full-length model, and the accuracy of model selection using the TASSER-QA quality assessment method. Finally, we analyze the overall performance and highlight some successful predictions of the pro-sp3-TASSER server.
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Template-based protein structure modeling using TASSER(VMT.).
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Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30318.
Template-based protein structure modeling is commonly used for protein structure prediction. Based on the observation that multiple template-based methods often perform better than single template-based methods, we further explore the use of a variable number of multiple templates for a given target in the latest variant of TASSER, TASSER(VMT) . We first develop an algorithm that improves the target-template alignment for a given template.
View Article and Find Full Text PDFPerformance of the Pro-sp3-TASSER server in CASP8.
Proteins
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Center for Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30318, USA.
The performance of the protein structure prediction server pro-sp3-TASSER in CASP8 is described. Compared to CASP7, the major improvement in prediction is in the quality of input models to TASSER. These improvements are due to the PRO-SP(3) threading method, the improved quality of contact predictions provided by TASSER_2.
View Article and Find Full Text PDFProtein structure prediction by pro-Sp3-TASSER.
Biophys J
March 2009
Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA.
An automated protein structure prediction algorithm, pro-sp3-Threading/ASSEmbly/Refinement (TASSER), is described and benchmarked. Structural templates are identified using five different scoring functions derived from the previously developed threading methods PROSPECTOR_3 and SP(3). Top templates identified by each scoring function are combined to derive contact and distant restraints for subsequent model refinement by short TASSER simulations.
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