Fracture may influence the serum and urine levels of bone turnover markers, however, the changes in bone markers seem to be not constant. The magnitude of change may be dependent on the size of the fractured bone, the amount of bone involved, and difference in bone markers. In patients with hip fracture, there was early increase in bone resorption markers within 2 weeks after fracture, and resorption markers started to decrease 2-3 months after fracture and stabilized close to prefracture level by about 6 months after fracture. Bone formation markers peaked later than bone resorption markers and remained elevated up to 1 year after fracture. This elevation in bone turnover markers reflects the repair process after fracture, and also immobilization following fracture, bone loss close to the fracture, and post-traumatic systemic reactions contribute to the accelerated bone formation and resorption.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Extracellular vesicles: essential agents in critical bone defect repair and therapeutic enhancement.
Mol Biol Rep
January 2025
Pediatric Cell, and Gene Therapy Research Center Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Bone serves as a fundamental structural component in the body, playing pivotal roles in support, protection, mineral supply, and hormonal regulation. However, critical-sized bone injuries have become increasingly prevalent, necessitating extensive medical interventions due to limitations in the body's capacity for self-repair. Traditional approaches, such as autografts, allografts, and xenografts, have yielded unsatisfactory results.
View Article and Find Full Text PDFCurrent and emerging bone resorption inhibitors for the treatment of osteoporosis.
Expert Opin Pharmacother
January 2025
Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece.
Introduction: Osteoporosis is a metabolic skeletal disease characterized by low bone mass and strength, and increased risk for fragility fractures. It is a major health issue in aging populations, due to fracture associated increased disability and mortality. Antiresorptive treatments are first line choices in most of the cases.
View Article and Find Full Text PDFComparison Between Nano-Hydroxyapatite/Beta-Tricalcium Phosphate Composite and Autogenous Bone Graft in Bone Regeneration Applications: Biochemical Mechanisms and Morphological Analysis.
Int J Mol Sci
December 2024
Department of Biology, School of Medicine, State University of Rio de Janeiro, Professor Manuel de Abreu, 444, Avenue, Rio de Janeiro 20550-170, Brazil.
It was assumed that only autogenous bone had appropriate osteoconductive and osteoindutive properties for bone regeneration, but this assumption has been challenged. Many studies have shown that synthetic biomaterials must be considered as the best choice for guided bone regeneration. The objective of this work is to compare the performances of nanohydroxyapatite/β-tricalcium phosphate (n-HA/β-TCP) composite and autogenous bone grafting in bone regeneration applications.
View Article and Find Full Text PDFHypoxia Promotes Osteoclast Differentiation by Weakening USP18-Mediated Suppression on the NF-κB Signaling Pathway.
Int J Mol Sci
December 2024
Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China.
Osteoporosis, a prevalent metabolic bone disorder, is characterized by reduced bone density and increased fracture risk. The pathogenesis of osteoporosis is closely associated with an imbalance in bone remodeling, in which the resorption function of osteoclasts exceeds the formation function of osteoblasts. Hypoxia has been implicated in the promotion of osteoclast differentiation and the subsequent development of osteoporosis.
View Article and Find Full Text PDFThe therapeutic potential of extracellular vesicles (EVs) in bone regeneration is noteworthy; however, their clinical application is impeded by low yield and limited efficacy. This study investigated the effect of low-intensity pulsed ultrasound (LIPUS) on the therapeutic efficacy of EVs derived from periodontal ligament stem cells (PDLSCs) and preliminarily explored its mechanism. PDLSCs were cultured with osteogenic media and stimulated with or without LIPUS, and then EVs and LIPUS-stimulated EVs (L-EVs) were isolated separately.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!