Talin is a large dimeric 270 kDa adapter protein which binds the cytoplasmic face of a subset of integrin beta-subunits and couples them to the actin cytoskeleton. Here we report the near complete 15N, 13C and 1H chemical shift assignments for the C-terminal actin-binding domain.
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Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation.
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Filamin A (FLNA) is an actin-binding protein that has been reported to interact with STIM1 modulating the activation of Orai1 channels. Cleaving of FLNA by calpain leads to a C-terminal fragment that is involved in a variety of functional and pathological events, including pro-oncogenic activity in different types of cancer. Here we show that full-length FLNA is downregulated in samples from colon cancer patients as well as in the adenocarcinoma cell line HT-29.
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JCI Insight
December 2024
Institute of BioInnovation, Biomedical Sciences Research Centre "Alexander Fleming," Vari-Athens, Greece.
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Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), 28049, Madrid, Spain.
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View Article and Find Full Text PDFA rare cause of epileptic encephalopathy: case report of a novel patient with PEHO-like phenotype and CCDC88A gene pathogenic variants.
Ital J Pediatr
September 2024
Medical Genetics Laboratory, Victor Babes National Institute of Pathology, Bucharest, 050096, Romania.
Article Synopsis
- * A case was reported involving a child from a nonconsanguineous family with significant developmental delays, severe seizures, and brain abnormalities, found to have two harmful variants in the CCDC88A gene.
- * The findings highlight the need for genetic screening for CCDC88A variants due to shared clinical features and brain malformations seen in affected individuals, pointing to consistent phenotypes.
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