Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.

Biomol NMR Assign

Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E6BT, UK.

Published: July 2007

AI Article Synopsis

  • The study focuses on NMR spectroscopy to analyze how different ligands and potential inhibitors interact with the enzyme UCH-L3.
  • UCH-L3 is a 26 kD human enzyme that belongs to the ubiquitin C-hydrolase family, which includes enzymes that target ubiquitin proteins.
  • The research provides the backbone resonance assignments crucial for understanding the structural features and interactions of UCH-L3.

Article Abstract

To facilitate NMR spectroscopy studies of interactions with various ligands and potential inhibitors, we report the NMR backbone resonance assignments for the 26 kD human enzyme UCH-L3, a member of the ubiquitin C-hydrolase family of ubiquitin-specific cysteine proteases.

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Source
http://dx.doi.org/10.1007/s12104-007-9012-5DOI Listing

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