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An integrated microfluidic device for large-scale in situ click chemistry screening. | LitMetric
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An integrated microfluidic device for large-scale in situ click chemistry screening.

Yanju Wang Wei-Yu Lin Kan Liu Rachel J Lin Matthias Selke Hartmuth C Kolb Nangang Zhang Xing-Zhong Zhao Michael E Phelps Clifton K F Shen Kym F Faull Hsian-Rong Tseng

Lab Chip

Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 570 Westwood Plaza, building 114, Los Angeles, CA 90095, USA.

Published: August 2009

An integrated microfluidic device has been developed to perform 1024 in situ click chemistry reactions in parallel using the bovine carbonic anhydrous II (bCAII) click chemistry system as a proof-of-concept study and a rapid hit identification approach using SPE purification and electrospray-ionization mass spectrometry, multiple reaction monitoring (MRM) analysis, all of which improves the sensitivity and throughput of the downstream analysis.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878189PMC
http://dx.doi.org/10.1039/b907430aDOI Listing

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