Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety.

Bioorg Med Chem Lett

Incyte Corporation, Experimental Station-E336, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA.

Published: September 2009

A novel series of carbamates was discovered as potent and selective HER-2 sheddase inhibitors. Significant enhancement in potency and selectivity was achieved through attenuating the P1 moiety, which was conventionally believed to be exposed to solvent.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.052DOI Listing

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