AI Article Synopsis
- The study focused on how different vehicles, chemical enhancers, and iontophoresis affect the skin's absorption of clobetasol propionate (CP) and mometasone furoate (MF).
- In vitro tests with pig ear skin revealed that sodium-deoxycholate (Na-DOC) gel significantly boosted the skin accumulation of both CP and MF, particularly within the stratum corneum and epidermis.
- The terpene derivative nerolidol enhanced skin accumulation of CP and MF without penetrating the skin, while iontophoresis improved MF absorption but did not affect CP; the combination of nerolidol and iontophoresis did not yield additional benefits for drug accumulation.
Article Abstract
The aim of this paper was to evaluate the effect of vehicle, chemical enhancer and iontophoresis on the skin accumulation of clobetasol propionate (CP) and mometasone furoate (MF). In vitro permeation experiments were performed using pig ear skin as barrier and HPLC as quantification method. The formulations tested were chitosan gels, sodium-deoxycholate gels and commercial creams of CP and MF. The results obtained indicate that Na-DOC gel had an enhancing effect on the skin accumulation of both active agents. This effect was more evident with CP especially in the stratum corneum and epidermis which are the target sites of topical steroidal treatment. Two terpene derivatives (D-limonene and nerolidol) and Transcutol P were evaluated as chemical penetration enhancers. Nerolidol produced considerable increase in the amount of CP and MF accumulated without any permeation across the skin. The application of electric current (anodal iontophoresis) to the gels improved the accumulation of MF while it did not effect the accumulation of CP. Due to the best accumulation results of nerolidol, the enhancement effect in combination with iontophoresis was also investigated. It was shown that, the combination of anodal iontophoresis and chemical enhancer (nerolidol) produced no further enhancement for both active agents.
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| http://dx.doi.org/10.1016/j.ijpharm.2009.07.018 | DOI Listing |
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