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Lambert-Eaton myasthenic syndrome revealing an abdominal neuroblastoma. | LitMetric

Lambert-Eaton myasthenic syndrome revealing an abdominal neuroblastoma.

J Pediatr Surg

Department of General Pediatric Surgery, University Hospital, Hôpital Sainte-Justine, Montréal, Quebec, Canada.

Published: August 2009

Lambert-Eaton myasthenic syndrome is a paraneoplastic syndrome that may reveal a primitive tumor. Neuroblastoma in children and small cell lung carcinoma in adults are the leading tumors revealed or expressed by paraneoplastic phenomena. The clinical neurologic manifestations of Lambert-Eaton myasthenic syndrome are muscular weakness, sleepiness, absence of reflexes, and dysautonomia. Neurologic manifestations are explained by the induction of an autoimmune response because of the presence of antigens that are expressed by the tumor. Neurologic paraneoplastic disorders may also be the result of toxicity of drugs, coagulopathy, infection, or metabolic diseases. We describe the case of a 13-month-old child with unusual neurologic symptoms because of the presence of an abdominal neuroblastoma.

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http://dx.doi.org/10.1016/j.jpedsurg.2009.04.023DOI Listing

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