Design, synthesis and antifungal activity of a series of novel analogs based on diphenyl ketones.

Chem Biol Drug Des

Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.

Published: June 2009

To find potent fungicides, 35 analogs of diphenyl ketones were synthesized and evaluated for their antifungal activity. These compounds possessed a furyl-carbonyl-phenyl skeleton. Bioassay results showed that the synthesized compounds were effective in promoting the antifungal activity of diphenyl ketones. Compound 3 showed the best activity against the four tested fungi (100%, 100%, 100% and 96.4%) and could be used as potent fungicide for further research.

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http://dx.doi.org/10.1111/j.1747-0285.2009.00820.xDOI Listing

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