To find potent fungicides, 35 analogs of diphenyl ketones were synthesized and evaluated for their antifungal activity. These compounds possessed a furyl-carbonyl-phenyl skeleton. Bioassay results showed that the synthesized compounds were effective in promoting the antifungal activity of diphenyl ketones. Compound 3 showed the best activity against the four tested fungi (100%, 100%, 100% and 96.4%) and could be used as potent fungicide for further research.
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http://dx.doi.org/10.1111/j.1747-0285.2009.00820.x | DOI Listing |
Nat Prod Res
January 2025
Department of Bioengineering and Biotechnology, Birla Institute of Technology, Ranchi, Jharkhand, India.
Current study investigates the medicinal applications of (Palash), the state flower of Jharkhand, India, focusing on synthesising biomodified copper oxide nanoparticles (CuO-NPs) and its antifungal properties. Flavonoid content in the flower extract was quantified by aluminium chloride colorimetric analysis. CuO-NPs were synthesised via co-precipitation method and then modified with methanolic flower extract.
View Article and Find Full Text PDFMol Divers
January 2025
Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Cyclotides are a class of plant-derived cyclic peptides having a distinctive structure with a cyclic cystine knot (CCK) motif. They are stable molecules that naturally play a role in plant defense. Till date, more than 750 cyclotides have been reported among diverse plant taxa belonging to Cucurbitaceae, Violaceae, Rubiaceae, Solanaceae, and Fabaceae.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Horticulture and Life Science, Yeungnam University, Gyeongsan 38541, Republic of Korea.
The development of resistance to traditional antifungal therapies has necessitated the exploration of alternative treatment strategies to effectively manage fungal infections, particularly those induced by (). This research investigates the possibility of integrating silver nanoparticles (AgNPs) with Terbinafine to improve antifungal effectiveness. Terbinafine, while potent, faces challenges with specific fungal strains, highlighting the need for strategies to enhance its treatment efficacy.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Oral candidiasis, predominantly caused by , presents significant challenges in treatment due to increasing antifungal resistance and biofilm formation. Antimicrobial photodynamic therapy (aPDT) using natural photosensitizers like riboflavin and hypericin offers a potential alternative to conventional antifungal therapies. : A systematic review was conducted to evaluate the efficacy of riboflavin- and hypericin-mediated aPDT in reducing Candida infections.
View Article and Find Full Text PDFPlants (Basel)
January 2025
Production System Unit, Natural Resources Institute Finland, 31600 Jokioinen, Finland.
Stinging nettle () is an herbaceous perennial plant native to Eurasia, wildly distributed throughout the temperate parts of the world. Although generally considered as a weed due to its fast growth and invasive capacity, stinging nettle is well suited to cultivation and is currently experiencing a revival as a beneficial crop due to its numerous potential applications. This interest reflects in an increasing number of scientific articles related to nettle in the last years.
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