AI Article Synopsis
- Recent research shows chronic exposure to cigarette smoke can lead to pancreatitis in rats, suggesting a potential link between smoking and pancreatic health.
- The study involved treating rats with cigarette smoke for varying durations and analyzing pancreatic tissue for inflammation and oxidative stress markers, like interleukin-6 levels and enzyme activities.
- Findings indicate that prolonged smoke exposure resulted in significant pancreatic inflammation and reduced antioxidant enzyme activity, supporting the idea that oxidative stress plays a role in the development of smoke-related pancreatitis.
Article Abstract
Background/aims: Recent findings with a rodent model of cigarette smoke inhalation revealed a causal relationship between chronic exposure to cigarette smoke and the development of pancreatitis. The present study was conducted to ascertain whether cigarette smoke induces oxidative stress in the rat pancreas concurrently with inflammation.
Methodology: Rats (six per treatment group) were treated for 0, 3, 6, 9, or 12 weeks with cigarette smoke (0.7 mg/L). Pancreatic tissues were examined for histological and pathological alterations and serum for changes in interleukin-6 concentration. Pancreatic expression and localization of alpha-smooth muscle actin, transforming growth factor-beta1, and collagen-1 were determined as measures of progressive inflammation/fibrosis. Pancreatic superoxide dismutase and glutathione peroxidase activities and malondialdehyde content were measured as indices of oxidative stress.
Results: Inflammatory cell infiltration and ductal hyperplasia were detected in pancreata after 12 weeks of treatment with cigarette smoke. The serum interleukin-6 concentration increased significantly and pancreatic glutathione peroxidase activity declined significantly after 12 weeks of treatment. No other significant changes were observed.
Conclusions: Pancreata of rats exposed chronically to cigarette smoke exhibit inflammation concurrently with suppression of glutathione peroxidase activity. These observations favor a role for oxidative stress in the induction of pancreatitis associated with chronic cigarette smoke inhalation.
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| http://dx.doi.org/10.1080/08958370802665937 | DOI Listing |
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