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The authors compared the effectiveness of the Seeking Safety group, cognitive-behavioral treatment for substance use disorder and posttraumatic stress disorder (PTSD), to an active comparison health education group (Women's Health Education [WHE]) within the National Institute on Drug Abuse's Clinical Trials Network. The authors randomized 353 women to receive 12 sessions of Seeking Safety (M = 6.2 sessions) or WHE (M = 6.0 sessions) with follow-up assessment 1 week and 3, 6, and 12 months posttreatment. Primary outcomes were the Clinician Administered PTSD Scale (CAPS), the PTSD Symptom Scale-Self Report (PSS-SR), and a substance use inventory (self-reported abstinence and percentage of days of use over 7 days). Intention-to-treat analysis showed large, clinically significant reductions in CAPS and PSS-SR symptoms (d = 1.94 and 1.12, respectively) but no reliable difference between conditions. Substance use outcomes were not significantly different over time between the two treatments and at follow-up showed no significant change from baseline. Study results do not favor Seeking Safety over WHE as an adjunct to substance use disorder treatment for women with PTSD and reflect considerable opportunity to improve clinical outcomes in community-based treatments for these co-occurring conditions.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795638 | PMC |
http://dx.doi.org/10.1037/a0016227 | DOI Listing |
Clin Cosmet Investig Dermatol
December 2024
Anticlock Clinic, Chandigarh, India.
Background: Facial contouring procedures are increasingly sought to address aesthetic concerns such as submental fat accumulation and lack of jawline definition. Cryolipolysis and hyaluronic acid (HA) injection have emerged as promising modalities for lower face contouring, targeting fat reduction and jawline enhancement, respectively.
Objective: This study aims to assess the efficacy and safety of a combined treatment approach involving cryolipolysis followed by HA injection for addressing lower face contour concerns.
J Ind Ecol
December 2024
Department of Environmental Science, Radboud Institute for Biological and Environmental Sciences Radboud University Nijmegen Nijmegen The Netherlands.
The emerging field of prospective life cycle assessment (pLCA) offers opportunities for evaluating the environmental impacts of possible future consumption shifts. One such shift involves a transition from meat-based to plant-forward diets, acknowledged to mitigate environmental impacts of the food system under present day conditions. Current diets are often meat intensive ("meat-based"), whilst "plant-forward" diets include mainly plant-based foods, encompassing flexitarian, vegetarian, and vegan diets.
View Article and Find Full Text PDFJ Environ Manage
December 2024
Federal University of Ouro Preto, Brazil. Electronic address:
This study introduces a comprehensive methodology for selecting blasthole diameters in open-pit mining, aiming to reduce the environmental impact while addressing the limitations of traditional empirical methods that often yield suboptimal productivity, cost efficiency. By integrating critical parameters such as bench height, rock and explosive properties, desired fragmentation size, production scale, and operational specifics, the methodology seeks to minimize negative effects on nearby communities while optimizing blasting practices. The methodology consists of four key steps: calculating potential diameters based on bench height, verifying influential factors affecting diameter selection, assessing environmental impacts of blasting activities, such as blasting-induced vibration and flyrock, and ultimately choosing the optimal diameter.
View Article and Find Full Text PDFFront Behav Neurosci
December 2024
Department of Neuroscience, Developmental, and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, United States.
Safety learning during threat and adversity is critical for behavioral adaptation, resiliency, and survival. Using a novel mouse paradigm involving thermal threat, we recently demonstrated that safety learning is highly susceptible to social isolation stress. Yet, our previous study primarily considered male mice and did not thoroughly scrutinize the relative impacts of stress on potentially distinct defensive mechanisms implemented by males and females during the thermal safety task.
View Article and Find Full Text PDFAJOG Glob Rep
February 2025
Department of Obstetrics and Gynecology, Michigan Medicine, Ann Arbor, MI (Thiyagarajan and Compton).
Background: About 5% to 13% of maternal mortality is directly related to unsafe abortion care. Despite the cultural stigmatization of abortions, Ghana has progressive abortion laws, healthcare guidelines, and clinical outcomes.
Objective: Our study's primary aim was to characterize abortion outcomes in Ghana.
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