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| http://dx.doi.org/10.7861/clinmedicine.9-3-207 | DOI Listing |
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Evidence of DNA methylation heterogeneity and epipolymorphism in kidney cancer tissue samples.
Oncogene
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Early Cancer Institute, Cancer Research UK Cambridge Centre, Cambridge Biomedical Campus, Cambridge, UK.
Clear cell renal cell carcinoma (ccRCC) is characterised by significant genetic heterogeneity, which has diagnostic and prognostic implications. Very limited evidence is available regarding DNA methylation heterogeneity. We therefore generate sequence level DNA methylation data on 136 multi-region tumour and normal kidney tissue from 18 ccRCC patients, along with matched whole exome sequencing (85 samples) and gene expression (47 samples) data on a subset of samples.
View Article and Find Full Text PDFThe management of people with epilepsy in a city wide care home service, the impact of a GP with Special Interest in epilepsy, and Enhanced Health in Care Homes Framework.
Epilepsy Behav
January 2025
Consultant Neurologist, Homerton University Hospital NHS Foundation Trust, Homerton Row, London E9 6SR, and UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Background: The incidence of epilepsy increases with age, especially in people diagnosed with dementia. Seizures in an elderly population are likely to have a focal onset, for which sodium channel blockers are the drug of choice. This study reviews the clinical needs and care of people with epilepsy (PWE) in a city wide care home service and assessing the impact of a GP with Special Interest in epilepsy (GPwSIe).
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Internal Medicine Salmaniya Medical Complex.
Introduction: Despite the high mortality rate of acute untreated pulmonary embolism (PE) at 30%, diagnosing PE is challenging. While the prevalence of PE has decreased in recent years, the overuse of computed tomography pulmonary angiography (CTPA) remains a concern. The National Institute for Health and Care Excellence (NICE) provides guidelines using the Wells score for PE assessment.
View Article and Find Full Text PDFReversal of Roux-en-Y Gastric Bypass: A Multi-Centric Analysis of Indications, Techniques, and Surgical Outcomes.
Obes Surg
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Department of Surgery and Transplantation, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
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Endovascular management of haemorrhage and vascular lesions in patients with multiple and/or severe injuries: a systematic review and clinical practice guideline update.
Eur J Trauma Emerg Surg
January 2025
Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Cologne, Germany.
Purpose: Our aim was to update evidence-based and consensus-based recommendations for the inhospital endovascular management of haemorrhage and vascular lesions in patients with multiple and/or severe injuries based on current evidence. This guideline topic is part of the 2022 update of the German Guideline on the Treatment of Patients with Multiple and/or Severe Injuries.
Methods: MEDLINE and Embase were systematically searched to June 2021.
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