Background: H1N2 is one of the main subtypes of influenza, which circulates in swine all over the world.
Objectives: To investigate the prevalence and genetic of H1N2 in swine of China.
Study Design: Two H1N2 swine influenza viruses were isolated from Tianjin and Guangdong province of China in 2004 and 2006, respectively. The molecular evolution of eight gene segments was analyzed.
Result: A/Swine/Tianjin/1/2004 has low identity with A/Swine/Guangdong/2006; in the phylogenetic tree of PA gene, A/Swine/Guangdong/1/2006 and A/Swine/Guangxi/1/2006 along with the H1N2 swine isolates of North America formed a cluster; and A/Swine/Tianjin/2004 and A/Swine/Zhejiang/2004, along with the classical H1N1 swine isolates formed another cluster; except that NA gene of A/Swine/Tianjin/1/2004 fell into the cluster of the H3N2 human influenza virus, indicating the reassortment between H3N2 human and H1N1 swine influenza viruses.
Conclusion: Two different genotypes of H1N2 appeared among pigs in China. A/swine/Guangdong/1/06 was probably from H1N2 swine influenza viruses of North America; while A/swine/Tianjin/1/04 maybe come from reassortments of classical H1N1 swine and H3N2 human viruses prevalent in North America.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcv.2009.06.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunization and challenge trials in a murine model using different inactivated recombinant vaccines against H1N1 swine influenza virus circulating in Brazil.
Vaccine
January 2025
Department of Preventive Veterinary Medicine, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:
In Brazil, at least four lineages of influenza A virus circulate pig population: 2009 H1N1 flu pandemic (pH1N1), human-seasonal origin H3N2, H1N1 and H1N2 (huH1 lineages) viruses. Studies related to the occurrence of swine influenza A virus (SIAV) in Brazilian herds have been detecting an increase of occurrence of huH1 lineages. This study aimed to construct recombinant vaccines against the huH1N1 virus and test the immunogens in a murine model.
View Article and Find Full Text PDFA neuraminidase-based inactivated influenza virus vaccine significantly reduced virus replication and pathology following homologous challenge in swine.
Vaccine
February 2025
USDA-ARS, National Animal Disease Center, Virus and Prion Research Unit, Ames, IA, USA. Electronic address:
Influenza A viruses (IAV) of subtypes H1N1, H1N2, and H3N2 are endemic in US domestic swine populations and contribute to significant economic losses annually and pose a persistent pandemic threat. Adjuvanted, whole-inactivated virus (WIV) vaccines are the primary countermeasure to control IAV in swine. The compositions of these vaccines are matched for hemagglutinin (HA) strain and content, often ignoring the other IAV glycoprotein, the neuraminidase (NA).
View Article and Find Full Text PDFPorcine Airway Organoid-Derived Well-Differentiated Epithelial Cultures as a Tool for the Characterization of Swine Influenza a Virus Strains.
Viruses
November 2024
Wageningen Bioveterinary Research, 8221 RA Lelystad, The Netherlands.
Article Synopsis
- Swine influenza A viruses (IAVsw) pose a health risk to both pigs and humans, showing varied levels of pathogenicity.
- Researchers created airway organoids from pig bronchus tissue to establish a model for testing the virulence of different IAVsw strains.
- In this model, the H3N2 strain caused more damage to lung cell structures than H1N2 or H1N1 strains, indicating the model's effectiveness for studying IAVsw virulence.
Effect of stabilizers on the detection of swine influenza A virus (swIAV) in spiked oral fluids over time.
Porcine Health Manag
November 2024
Clinic for Swine at the Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Oberschleißheim, Germany.
Background: Aggregated samples such as oral fluids (OFs) display an animal friendly and time and cost-efficient sample type for swine Influenza A virus (swIAV) monitoring. However, further molecular and biological characterization of swIAV is of particular significance. The reportedly inferior suitability of aggregated samples for subtyping of swIAV presents a major drawback compared to nasal swabs, still considered the most appropriate sample type for this purpose (Garrido-Mantilla et al.
View Article and Find Full Text PDFArticle Synopsis
- - Since 2013, there have been 167 cases of people infected with special flu viruses from pigs in the U.S. called swine-origin influenza A.
- - Most of these viruses had a change in their genes that makes them resistant to certain medicines, but none were resistant to another type of medicine called neuraminidase inhibitors.
- - Scientists did tests to find out how well these viruses respond to treatments and discovered that one specific change in the virus made it much harder to treat with a medicine called baloxavir.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!